Pavlova M V, Skvortsova L A, Kondakova M N, Kovaleva R G
Probl Tuberk Bolezn Legk. 2005(11):30-4.
The paper presents the results of a follow-up and treatment of 75 adolescents with pulmonary tuberculosis. It assesses the predictive value of different alleles of the gene HLA-DRB1 and the genotype of Mycobacterium tuberculosis for the clinical course of pulmonary tuberculosis in the adolescents. An algorithm of examination of an adolescent with tuberculosis has been developed, by using a complex of genetic parameters. A differential approach to tuberculosis prevention and treatment regimens is presented by taking into account of genetic characteristics of gross and microorganisms.
本文介绍了对75例青少年肺结核患者的随访及治疗结果。评估了基因HLA - DRB1不同等位基因以及结核分枝杆菌基因型对青少年肺结核临床病程的预测价值。通过使用一系列遗传参数，制定了青少年结核病的检查算法。考虑到宿主和微生物的遗传特征，提出了针对结核病预防和治疗方案的差异化方法。
