Skvortsova L A, Pavlova M V, Kondakova M N, Vinogradova T I, Kovaleva R G, Archakova L I
Probl Tuberk Bolezn Legk. 2008(12):38-40.
It is as for now evident that in-depth researches of the genotype of a patient are needed to enhance the efficiency of therapeutic measures. The purpose of the present study was to enhance the efficiency of complex antituberculous therapy, by genetically identifying the allelic polymorphism of the HLA-DRB1* gene in a person who had ill with tuberculosis. The material of the study was the results of a followup and treatment of 100 patients with pulmonary tuberculosis. The subject of a special study was the molecular typing of the HLA genes of the DRB1* locus by polymerase chain reaction (PCR-SSP). The findings suggest that an individual approach to choosing treatment regimens (chemotherapy and pathogenetic therapy) for patients with pulmonary tuberculosis, by taking into account the HLA-DRB1* genotype enables one to enhance the efficiency of treatment in the major clinical and X-ray parameters.
目前很明显，需要对患者的基因型进行深入研究，以提高治疗措施的效率。本研究的目的是通过对结核病患者的HLA - DRB1基因的等位基因多态性进行基因鉴定，提高联合抗结核治疗的效率。研究材料是100例肺结核患者的随访和治疗结果。一项专门研究的对象是通过聚合酶链反应（PCR - SSP）对DRB1位点的HLA基因进行分子分型。研究结果表明，对于肺结核患者，通过考虑HLA - DRB1*基因型，采取个性化方法选择治疗方案（化疗和病因治疗），能够提高主要临床和X线参数方面的治疗效果。
