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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Buckley Nick A, Eddleston Michael, Dawson Andrew H

South Asian Clinical Toxicology Research Collaboration, Department of Clinical Medicine, University of Colombo, Colombo.

Clin Exp Pharmacol Physiol. 2005 Nov;32(11):999-1005. doi: 10.1111/j.1440-1681.2005.04298.x.

Pesticide poisoning kills hundreds of thousands of people in the Asia-Pacific region each year. The majority of deaths are from deliberate self-poisoning with organophosphorus pesticides (OP), aluminium phosphide and paraquat. The current response from a public health, medical and research perspective is inadequate. 2. There are few proven or effective treatments; in addition, very little clinical research has been performed to transfer antidotes shown to work in animal studies into clinical practice. 3. The human toxicity of pesticides is poorly studied and better information may inform a more sustained and appropriate regulatory response. Further understanding may also lead to improvements in diagnosis and treatment. 4. The few effective treatments are not being recommended or delivered in an optimal and timely fashion to poisoned patients. A regional approach to facilitate appropriate pricing, packaging and delivery of antidotes is required.

每年，亚太地区有数十万人死于农药中毒。大多数死亡是由于故意自服有机磷农药（OP）、磷化铝和百草枯所致。从公共卫生、医学和研究角度来看，目前的应对措施并不充分。2. 几乎没有经过验证的有效治疗方法；此外，很少有临床研究将在动物研究中显示有效的解毒剂应用于临床实践。3. 对农药的人体毒性研究不足，更多信息可能有助于做出更持续、恰当的监管反应。进一步的了解也可能带来诊断和治疗方面的改善。4. 少数有效的治疗方法没有以最佳和及时的方式推荐给中毒患者或应用于他们。需要采取一种区域性方法来促进解毒剂的合理定价、包装和供应。

Buckley Nick A, Eddleston Michael, Dawson Andrew H

South Asian Clinical Toxicology Research Collaboration, Department of Clinical Medicine, University of Colombo, Colombo.

Clin Exp Pharmacol Physiol. 2005 Nov;32(11):999-1005. doi: 10.1111/j.1440-1681.2005.04298.x.

Pesticide poisoning kills hundreds of thousands of people in the Asia-Pacific region each year. The majority of deaths are from deliberate self-poisoning with organophosphorus pesticides (OP), aluminium phosphide and paraquat. The current response from a public health, medical and research perspective is inadequate. 2. There are few proven or effective treatments; in addition, very little clinical research has been performed to transfer antidotes shown to work in animal studies into clinical practice. 3. The human toxicity of pesticides is poorly studied and better information may inform a more sustained and appropriate regulatory response. Further understanding may also lead to improvements in diagnosis and treatment. 4. The few effective treatments are not being recommended or delivered in an optimal and timely fashion to poisoned patients. A regional approach to facilitate appropriate pricing, packaging and delivery of antidotes is required.

每年，亚太地区有数十万人死于农药中毒。大多数死亡是由于故意自服有机磷农药（OP）、磷化铝和百草枯所致。从公共卫生、医学和研究角度来看，目前的应对措施并不充分。2. 几乎没有经过验证的有效治疗方法；此外，很少有临床研究将在动物研究中显示有效的解毒剂应用于临床实践。3. 对农药的人体毒性研究不足，更多信息可能有助于做出更持续、恰当的监管反应。进一步的了解也可能带来诊断和治疗方面的改善。4. 少数有效的治疗方法没有以最佳和及时的方式推荐给中毒患者或应用于他们。需要采取一种区域性方法来促进解毒剂的合理定价、包装和供应。