Lim Cathy, Brown Pam
Honorary Research Fellow, Skin and Cancer Foundation Australia, Darlinghurst, New South Wales, Australia.
Australas J Dermatol. 2006 Feb;47(1):37-40. doi: 10.1111/j.1440-0960.2006.00220.x.
SUMMARY Psoriasis is a chronic fluctuating dermatosis with demonstrable impact on patients' quality of life. Our aim was to investigate if narrowband UVB phototherapy administered to psoriatic patients in a standardized manner leads to an improvement in patients' perceived quality of life. A total of 138 patients with psoriasis were recruited from referrals to the Skin and Cancer Foundation, Australia between January 1998 and September 2002. Patients had psoriasis inadequately controlled by topical therapies alone and no contraindications to the use of phototherapy. Patients completed a pre- and post-therapy questionnaire on quality of life parameters. The differences in mean and standard deviation of quality of life parameters were measured using a paired sample t-test based on pre- and post-phototherapy questionnaires. Ninety patients were included in the study. Forty-eight patients were excluded as they had not completed post-phototherapy questionnaires. The course of narrowband UVB phototherapy was found to significantly improve quality of life in psoriasis patients (P <or= 0.005). We conclude that narrowband UVB phototherapy improves quality of life in patients with psoriasis.
摘要 银屑病是一种慢性波动性皮肤病，对患者的生活质量有明显影响。我们的目的是研究以标准化方式对银屑病患者进行窄谱中波紫外线（NB-UVB）光疗是否能改善患者的生活质量。1998年1月至2002年9月期间，从澳大利亚皮肤与癌症基金会的转诊患者中招募了138例银屑病患者。这些患者仅通过局部治疗无法充分控制病情，且无光疗使用禁忌证。患者在治疗前和治疗后完成了关于生活质量参数的问卷。基于光疗前后的问卷，使用配对样本t检验测量生活质量参数的均值和标准差差异。90例患者纳入研究。48例患者因未完成光疗后问卷而被排除。结果发现，窄谱中波紫外线光疗疗程能显著改善银屑病患者的生活质量（P≤0.005）。我们得出结论，窄谱中波紫外线光疗可改善银屑病患者的生活质量。
