Prins Mandy, Krabbe Paul F M, Swinkels Quintus O J, de Boo Theo, van de Kerkhof Peter C M, van der Valk Pieter G M
Department of Dermatology, Radboud University Nijmegen Medical Centre, The Netherlands.
Acta Derm Venereol. 2005;85(4):304-10. doi: 10.1080/00015550510027801.
Psoriasis is a chronic skin disease with substantial impact on patients' social and relational ways of living and subsequently on their quality of life. The aim of this study was to evaluate the health-related quality of life (HRQoL) of patients with moderate to severe psoriasis treated with short contact dithranol treatment, UVB phototherapy or inpatient dithranol treatment. HRQoL was evaluated in an open randomized multicentre study by appliance of the Dutch short form of the Sickness Impact Profile and the Psoriasis Disability Index; 250 patients were included. Successful short contact dithranol treatment and UVB phototherapy both led to a comparable improvement in HRQoL immediately after treatment until the end of the follow-up (maximum 1 year). Inpatients experienced a more impaired HRQoL and showed no significant improvement in HRQoL directly following treatment. At the end of the study HRQoL became comparable for all treatment groups. All three treatments led to substantial improvement in HRQoL; however, patients treated by short contact treatment or UVB showed a better HRQoL than inpatients.
银屑病是一种慢性皮肤病，对患者的社交及生活方式有重大影响，进而影响其生活质量。本研究旨在评估采用短期接触蒽林治疗、紫外线B光疗或住院蒽林治疗的中重度银屑病患者的健康相关生活质量（HRQoL）。通过应用荷兰版简短疾病影响量表和银屑病残疾指数，在一项开放性随机多中心研究中对HRQoL进行评估；共纳入250例患者。成功的短期接触蒽林治疗和紫外线B光疗在治疗后直至随访结束（最长1年）均使HRQoL得到了类似程度的改善。住院患者的HRQoL受损更严重，且在治疗后HRQoL未显示出显著改善。在研究结束时，所有治疗组的HRQoL变得相当。所有三种治疗均使HRQoL得到了显著改善；然而，接受短期接触治疗或紫外线B光疗的患者的HRQoL优于住院患者。
