Zhang Xia, Li Tian-Ran, Chen Zhang-Shu, Ouyang Xue-Nong
Department of Oncology, Nanjing Command Fuzhou General Hospital, Fuzhou, Fujian 350025, P. R. China.
Ai Zheng. 2006 Jan;25(1):66-8.
BACKGROUND & OBJECTIVE: Positron emission tomography-computed tomography (PET-CT) is a new bio-imaging system which combined metabolic with anatomic imaging. This system has better three-dimensional definition and earlier tumor detection potential. This study was to compare the accuracy of tumor antigen detection combined with CT scan with PET-CT for lung cancer diagnosis and staging.
A total of 43 lung cancer patients diagnosed by operation or acupuncture, received breast CT scan, tumor antigen detection, and PET-CT scan, were selected. The accuracies of these 2 methods and their impacts on lung cancer staging were compared.
The accurate diagnosis rate of tumor antigen detection combined with CT scan was 67.44%, and that of PET-CT scan was 90.70%. Local focus detection rates were 86.05% and 95.35%, respectively; mediastinal lymph nodes detection rates were 65.12% and 83.72%, respectively. PET-CT detected 6 cases of distant metastasis which were not detected by tumor antigen detection combined with CT scan. Compared with CT scan, 5 (11.63%) cases were upstaged and 7 (16.28%) cases were downstaged by PET-CT, which led to therapeutic strategy changes in 4 (9.3%) cases.
Compare with tumor antigen detection combined with CT scan, PET-CT scan is more sensitive and accurate in diagnosing and staging lung cancer.
正电子发射断层扫描-计算机断层扫描（PET-CT）是一种将代谢成像与解剖成像相结合的新型生物成像系统。该系统具有更好的三维清晰度和更早检测肿瘤的潜力。本研究旨在比较肿瘤抗原检测联合CT扫描与PET-CT在肺癌诊断和分期中的准确性。
选取43例经手术或穿刺确诊的肺癌患者，分别接受胸部CT扫描、肿瘤抗原检测及PET-CT扫描。比较这两种方法的准确性及其对肺癌分期的影响。
肿瘤抗原检测联合CT扫描的准确诊断率为67.44%，PET-CT扫描的准确诊断率为90.70%。局部病灶检测率分别为86.05%和95.35%；纵隔淋巴结检测率分别为65.12%和83.72%。PET-CT检测出6例肿瘤抗原检测联合CT扫描未发现的远处转移。与CT扫描相比，PET-CT使5例（11.63%）患者分期上调，7例（16.28%）患者分期下调，其中4例（9.3%）患者的治疗策略因此改变。
与肿瘤抗原检测联合CT扫描相比，PET-CT在肺癌诊断和分期方面更敏感、准确。
