Gottesman Michael M, Ling Victor
Laboratory of Cell Biology, The Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
FEBS Lett. 2006 Feb 13;580(4):998-1009. doi: 10.1016/j.febslet.2005.12.060. Epub 2005 Dec 28.
The discovery and characterization of P-glycoprotein, an energy-dependent multidrug efflux pump, as a mechanism of multidrug resistance in cancer is generally accepted as a significant contribution to the ongoing effort to end death and suffering from this disease. The historical reflections of Victor Ling and Michael Gottesman concerning the early years of this research highlight the important contributions of the multidisciplinary teams involved in these studies, and illustrate how technological developments in biochemistry and molecular and cell biology enabled this discovery.
P-糖蛋白作为一种能量依赖性多药外排泵,其发现和特性表征被认为是癌症多药耐药机制,这一发现对当前致力于终结该疾病导致的死亡和痛苦的努力做出了重大贡献。Victor Ling和Michael Gottesman对该研究早期的历史回顾突出了参与这些研究的多学科团队的重要贡献,并阐明了生物化学以及分子和细胞生物学方面的技术发展是如何促成这一发现的。