Zhao Yu, Wang Shuxiao, Aunan Kristin, Seip Hans Martin, Hao Jiming
Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, PR China.
Sci Total Environ. 2006 Aug 1;366(2-3):500-13. doi: 10.1016/j.scitotenv.2005.10.010. Epub 2006 Jan 10.
Lung cancer is a serious health problem in China, as in the rest of the world. Many studies have already proved that air pollution as well as other environmental factors can increase the risk of lung cancer. Based on epidemiological studies carried out in China, this paper proposes odds ratios (OR) to evaluate the risk of lung cancer from indoor air pollution for the Chinese population by applying the method of meta-analysis. For domestic coal use for heating and cooking, the pooled OR values are 1.83 (95% CI: 0.62-5.41) and 2.66 (1.39-5.07) for women and both sexes, respectively. For indoor exposure to coal dust, the OR values are 2.52 (95% CI: 1.94-3.28) and 2.42 (1.62-3.63) for women and both sexes, respectively. Cooking oil vapor is another factor increasing lung cancer risk. The OR values are 2.12 (95%CI: 1.81-2.47), 1.78 (1.50-2.12) and 6.20 (2.88-13.32) for nonsmoking women, women, and both sexes, respectively. Regarding environmental tobacco smoke, the pooled OR values are 1.70 (95% CI: 1.32-2.18) and 1.64 (1.29-2.07) for nonsmoking women and both sexes, respectively. Funnel plots with statistical test have been applied to examine the publication bias, and the results implied that the analysis of coal consumption and cooking oil pollution might be affected by publication bias. The meta-analysis results confirm the association between lung cancer and indoor air pollution for the Chinese population.
与世界其他地区一样,肺癌在中国也是一个严重的健康问题。许多研究已经证明,空气污染以及其他环境因素会增加患肺癌的风险。基于在中国进行的流行病学研究,本文通过应用荟萃分析方法,提出比值比(OR)来评估中国人群因室内空气污染患肺癌的风险。对于用于取暖和烹饪的家用煤,女性和两性的合并OR值分别为1.83(95%CI:0.62 - 5.41)和2.66(1.39 - 5.07)。对于室内接触煤尘,女性和两性的OR值分别为2.52(95%CI:1.94 - 3.28)和2.42(1.62 - 3.63)。食用油烟雾是另一个增加肺癌风险的因素。非吸烟女性、女性和两性的OR值分别为2.12(95%CI:1.81 - 2.47)、1.78(1.50 - 2.12)和6.20(2.88 - 13.32)。对于环境烟草烟雾,非吸烟女性和两性的合并OR值分别为1.70(95%CI:1.32 - 2.18)和1.64(1.29 - 2.07)。已应用带有统计检验的漏斗图来检验发表偏倚,结果表明煤炭消耗和食用油污染的分析可能受发表偏倚影响。荟萃分析结果证实了中国人群肺癌与室内空气污染之间的关联。