Müller Christian P, Huston Joseph P
Institute of Physiological Psychology I and Center for Biological and Medical Research, University of Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Trends Pharmacol Sci. 2006 Feb;27(2):105-12. doi: 10.1016/j.tips.2005.12.003. Epub 2006 Jan 6.
Cocaine is a drug of abuse that has complex neurochemical and behavioural profiles. When it became evident that models that involve only dopamine do not fully explain the complex effects of cocaine on behaviour, the focus of research expanded to include the 5-hydroxytryptamine (5-HT) system in the brain. The 5-HT system comprises several subtypes of 5-HT receptors, which contribute differentially to the various behavioural effects of cocaine. In this article, we describe which subtypes regulate behaviours that are related to cocaine addiction and how they might provide new therapeutic approaches. Numerous subpopulations of each 5-HT receptor can be distinguished according to their location in the brain. We also discuss how these subpopulations relate to the effects of 5-HT-receptor stimulation at the systemic level. These insights provide a new receptor-based approach for understanding the 5-HT mechanisms that subserve the actions of cocaine and possible pharmacotherapies against cocaine addiction.
可卡因是一种滥用药物，具有复杂的神经化学和行为特征。当仅涉及多巴胺的模型显然无法完全解释可卡因对行为的复杂影响时，研究重点扩大到包括大脑中的5-羟色胺（5-HT）系统。5-HT系统由几种5-HT受体亚型组成，它们对可卡因的各种行为影响有不同的作用。在本文中，我们描述了哪些亚型调节与可卡因成瘾相关的行为，以及它们如何可能提供新的治疗方法。根据其在大脑中的位置，可以区分每种5-HT受体的众多亚群。我们还讨论了这些亚群如何与全身水平上5-HT受体刺激的作用相关。这些见解为理解可卡因作用的5-HT机制以及针对可卡因成瘾的可能药物治疗提供了一种基于受体的新方法。
