Cunningham K A, Bradberry C W, Chang A S, Reith M E
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77555-1031, USA.
Behav Brain Res. 1996;73(1-2):93-102. doi: 10.1016/0166-4328(96)00077-0.
Cocaine is a highly abused psychostimulant which is a local anesthetic and inhibitor of the reuptake of dopamine (DA), serotonin (5-HT) and norepinephrine (NE). This manuscript details a brief summary and the primary conclusions of several presentations geared to present recent pharmacological analyses of the interaction of cocaine with 5-HT systems. These data illustrate the complexity of actions for cocaine in the brain and emphasize that, to fully understand the mechanisms which underlie its potent behavioural effects, the impact of this drug on 5-HT function as well as the interactions between 5-HT and the function of DA mesolimbic pathways must be considered.
可卡因是一种被高度滥用的精神兴奋剂，它是一种局部麻醉剂，也是多巴胺（DA）、5-羟色胺（5-HT）和去甲肾上腺素（NE）再摄取的抑制剂。本手稿详细介绍了几场讲座的简短总结和主要结论，这些讲座旨在展示可卡因与5-羟色胺系统相互作用的最新药理学分析。这些数据说明了可卡因在大脑中作用的复杂性，并强调，为了充分理解其强大行为效应背后的机制，必须考虑这种药物对5-羟色胺功能的影响以及5-羟色胺与多巴胺中脑边缘通路功能之间的相互作用。
