Katakura Hiromichi, Takenaka Kazumasa, Nakagawa Masatsugu, Sonobe Makoto, Adachi Masashi, Ito Shinya, Wada Hiromi, Tanaka Fumihiro
Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Lung Cancer. 2006 Mar;51(3):323-8. doi: 10.1016/j.lungcan.2005.10.017. Epub 2006 Jan 6.
Maspin is a member of the serpin (serine protease inhibitor) superfamily, and some experimental studies revealed a potential tumor suppressor activity of maspin. To reveal clinical significance of maspin status in non-small cell lung cancer (NSCLC), we quantitatively evaluated maspin gene expression in lung primary tumors cut from a total of 55 resected NSCLC patients. Maspin expression in squamous cell carcinoma (Sq) was significantly higher than that in adenocarcinoma (Ad, p=0.011). Five-year overall survival rates of maspin-high and maspin-low patients were 67.7 and 41.4%, respectively, demonstrating a significant favorable prognosis of maspin-high patients (log-rank, p=0.042). A multivariate analysis confirmed that high maspin expression was an independent and significant factor to predict a favorable overall survival (p=0.031). These results suggested that maspin expression was significantly increased in Sq than in Ad, and that increased maspin expression was a significant factor to predict a favorable prognosis in resected NSCLC.
Maspin是丝氨酸蛋白酶抑制剂（serpin）超家族的成员，一些实验研究揭示了maspin具有潜在的肿瘤抑制活性。为了揭示maspin状态在非小细胞肺癌（NSCLC）中的临床意义，我们对55例接受手术切除的NSCLC患者的肺原发肿瘤中maspin基因表达进行了定量评估。肺鳞状细胞癌（Sq）中的maspin表达显著高于腺癌（Ad，p = 0.011）。maspin高表达和低表达患者的5年总生存率分别为67.7%和41.4%，表明maspin高表达患者的预后明显较好（对数秩检验，p = 0.042）。多因素分析证实，maspin高表达是预测良好总生存的独立且显著因素（p = 0.031）。这些结果表明，Sq中的maspin表达显著高于Ad，且maspin表达增加是预测手术切除的NSCLC患者预后良好的重要因素。
