Maspin基因表达是切除的非小细胞肺癌（NSCLC）的一个重要预后因素。NSCLC中的Maspin。

Maspin gene expression is a significant prognostic factor in resected non-small cell lung cancer (NSCLC). Maspin in NSCLC.

作者信息

Katakura Hiromichi, Takenaka Kazumasa, Nakagawa Masatsugu, Sonobe Makoto, Adachi Masashi, Ito Shinya, Wada Hiromi, Tanaka Fumihiro

机构信息

Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan.

出版信息

Lung Cancer. 2006 Mar;51(3):323-8. doi: 10.1016/j.lungcan.2005.10.017. Epub 2006 Jan 6.

DOI:10.1016/j.lungcan.2005.10.017

PMID:16406136

Abstract

Maspin is a member of the serpin (serine protease inhibitor) superfamily, and some experimental studies revealed a potential tumor suppressor activity of maspin. To reveal clinical significance of maspin status in non-small cell lung cancer (NSCLC), we quantitatively evaluated maspin gene expression in lung primary tumors cut from a total of 55 resected NSCLC patients. Maspin expression in squamous cell carcinoma (Sq) was significantly higher than that in adenocarcinoma (Ad, p=0.011). Five-year overall survival rates of maspin-high and maspin-low patients were 67.7 and 41.4%, respectively, demonstrating a significant favorable prognosis of maspin-high patients (log-rank, p=0.042). A multivariate analysis confirmed that high maspin expression was an independent and significant factor to predict a favorable overall survival (p=0.031). These results suggested that maspin expression was significantly increased in Sq than in Ad, and that increased maspin expression was a significant factor to predict a favorable prognosis in resected NSCLC.

摘要

Maspin是丝氨酸蛋白酶抑制剂（serpin）超家族的成员，一些实验研究揭示了maspin具有潜在的肿瘤抑制活性。为了揭示maspin状态在非小细胞肺癌（NSCLC）中的临床意义，我们对55例接受手术切除的NSCLC患者的肺原发肿瘤中maspin基因表达进行了定量评估。肺鳞状细胞癌（Sq）中的maspin表达显著高于腺癌（Ad，p = 0.011）。maspin高表达和低表达患者的5年总生存率分别为67.7%和41.4%，表明maspin高表达患者的预后明显较好（对数秩检验，p = 0.042）。多因素分析证实，maspin高表达是预测良好总生存的独立且显著因素（p = 0.031）。这些结果表明，Sq中的maspin表达显著高于Ad，且maspin表达增加是预测手术切除的NSCLC患者预后良好的重要因素。