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24S-羟基胆固醇的脑脊液水平是否是轻度认知障碍的敏感生物标志物?

Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?

作者信息

Leoni Valerio, Shafaati Marjan, Salomon Alina, Kivipelto Miia, Björkhem Ingemar, Wahlund Lars-Olof

机构信息

Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital in Huddinge, Stockholm, Sweden.

出版信息

Neurosci Lett. 2006;397(1-2):83-7. doi: 10.1016/j.neulet.2005.11.046. Epub 2006 Jan 6.

Abstract

There is a need for effective biomarkers showing whether or not a patient with mild cognitive impairment (MCI) will progress to Alzheimer's disease (AD) with dementia. At the present three cerebrospinal fluid (CSF) biomarkers are in general use: total tau, phospho-tau and beta-Amyloid. These markers are regarded to have high capacity to differentiate early AD from normal ageing. We have analysed CSF levels of a new marker for neuronal degeneration, 24S-hydroxycholesterol (24OHC) in patients with MCI. For reasons of comparison, we also analysed these levels in patients with AD. There was a significant correlation between CSF levels of 24OHC and total tau (as well as phospho-tau) in both groups of patients. Fifty percent of the patients contemplated for MCI were found to have elevated levels of 24OHC (using a 95th upper percentile set cut-off). All the MCI patients with normal levels of 24OHC had normal levels of the other markers. In patients with AD, the percentages of those with increased levels of 24OHC, tau and phospho tau were similar (55-67%). In this pilot study, we discuss the possibility that 24OHC may be a sensitive test for MCI.

摘要

需要有效的生物标志物来表明轻度认知障碍(MCI)患者是否会进展为伴有痴呆的阿尔茨海默病(AD)。目前普遍使用三种脑脊液(CSF)生物标志物:总tau蛋白、磷酸化tau蛋白和β-淀粉样蛋白。这些标志物被认为具有较高的能力来区分早期AD与正常衰老。我们分析了MCI患者中一种新的神经元变性标志物24S-羟基胆固醇(24OHC)的脑脊液水平。为了进行比较,我们还分析了AD患者的这些水平。两组患者脑脊液中24OHC水平与总tau蛋白(以及磷酸化tau蛋白)之间存在显著相关性。发现50%的MCI患者24OHC水平升高(采用第95百分位数设定的临界值)。所有24OHC水平正常的MCI患者其他标志物水平也正常。在AD患者中,24OHC、tau蛋白和磷酸化tau蛋白水平升高的患者百分比相似(55%-67%)。在这项初步研究中,我们讨论了24OHC可能是MCI敏感检测指标的可能性。

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