GG：一个参与噬菌体LTF装置并与人类MEB和非综合征性听力损失疾病有关的结构域。

GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases.

作者信息

Guo Jinhu, Cheng Haipeng, Zhao Shouyuan, Yu Long

机构信息

Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, IL 60637, USA.

出版信息

FEBS Lett. 2006 Jan 23;580(2):581-4. doi: 10.1016/j.febslet.2005.12.076. Epub 2006 Jan 3.

DOI:10.1016/j.febslet.2005.12.076

PMID:16406369

Abstract

Here, we report the identification of a novel domain--GG (domain in KIAA1199, FAM3, POMGnT1 and Tmem2 proteins, with two well-conserved glycine residues), present in eukaryotic FAM3 superfamily (FAM3A, FAM3B, FAM3C and FAM3D), POMGnT1 (protein O-linked mannose beta-1,2-N-acetylglucosaminyltransferase), TEM2 proteins as well as phage gp35 proteins. GG domain has been revealed to be implicated in muscle-eye-brain disease and non-syndromic hearing loss. The presence of GG domain in Bacteriophage gp35 hinge connector of long tail fiber might reflect the horizontal gene transfer from organisms. And we proposed that GG domain might function as important structural element in phage LTF.

摘要

在此，我们报告鉴定出一个新的结构域——GG（存在于KIAA1199、FAM3、POMGnT1和Tmem2蛋白中的结构域，有两个高度保守的甘氨酸残基），它存在于真核生物FAM3超家族（FAM3A、FAM3B、FAM3C和FAM3D）、POMGnT1（蛋白O-连接甘露糖β-1,2-N-乙酰葡糖胺基转移酶）、TEM2蛋白以及噬菌体gp35蛋白中。GG结构域已被发现与肌肉-眼-脑疾病和非综合征性听力损失有关。噬菌体gp35长尾纤维铰链连接体中存在GG结构域可能反映了来自生物体的水平基因转移。并且我们提出GG结构域可能在噬菌体长尾纤维中作为重要的结构元件发挥作用。