Shioiri T, Oshitani Y, Kato T, Murashita J, Hamakawa H, Inubushi T, Nagata T, Takahashi S
Department of Psychiatry, Shiga University of Medical Science, Japan.
Psychol Med. 1996 Mar;26(2):431-4. doi: 10.1017/s0033291700034838.
The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by magnetic resonance imaging (MRI). Significantly higher incidence of Grade 3-4 CSP (moderate to large) compared with the controls was found only in the schizophrenics. When a broader interpretation of CSP, including indeterminant (Grade 1) and small (Grade 2) CSP was used, three additional patients with bipolar disorder were found to have Grade 1-2 CSP, and the total prevalence of Grade 1-4 CSP in the patients with bipolar disorder was significantly higher than that in the control subjects but slightly lower than that in the schizophrenic patients. CSP was not observed in any patient with major depression. There were no differences between the patients with and without CSP in age, sex, education, or the duration of illness. These findings are consistent with the hypothesis that neurodevelopmental abnormality may be present in schizophrenia, and such an abnormality may also be present in some patients with bipolar disorder.
通过磁共振成像（MRI）对113例情感障碍患者（69例双相情感障碍患者和44例重度抑郁症患者）、40例精神分裂症患者和92例对照者进行了透明隔腔（CSP）发生率的检查。CSP在神经病理学中一直被广泛认为是一种临床意义不大的发育异常。结果发现，仅在精神分裂症患者中，3-4级CSP（中度至重度）的发生率显著高于对照组。当对CSP进行更广泛的解释，包括不确定（1级）和小（2级）CSP时，发现另外3例双相情感障碍患者有1-2级CSP，双相情感障碍患者中1-4级CSP的总患病率显著高于对照组，但略低于精神分裂症患者。在任何重度抑郁症患者中均未观察到CSP。有CSP和无CSP的患者在年龄、性别、教育程度或病程方面均无差异。这些发现与精神分裂症可能存在神经发育异常的假设一致，并且这种异常也可能存在于一些双相情感障碍患者中。
