Ungar Daniel, Oka Toshihiko, Krieger Monty, Hughson Frederick M
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Trends Cell Biol. 2006 Feb;16(2):113-20. doi: 10.1016/j.tcb.2005.12.004. Epub 2006 Jan 10.
The conserved oligomeric Golgi (COG) complex is essential for establishing and/or maintaining the structure and function of the Golgi apparatus. The Golgi apparatus, in turn, has a central role in protein sorting and glycosylation within the eukaryotic secretory pathway. As a consequence, COG mutations can give rise to human genetic diseases known as congenital disorders of glycosylation. We review recent results from studies of yeast, worm, fly and mammalian COG that provide evidence that COG might function in retrograde vesicular trafficking within the Golgi apparatus. This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function.
保守寡聚高尔基体（COG）复合体对于高尔基体的结构和功能的建立及/或维持至关重要。反过来，高尔基体在真核生物分泌途径中的蛋白质分选和糖基化过程中起着核心作用。因此，COG突变可引发被称为先天性糖基化障碍的人类遗传疾病。我们综述了近期对酵母、线虫、果蝇和哺乳动物COG的研究结果，这些结果表明COG可能在高尔基体逆行囊泡运输中发挥作用。这一假说通过假定COG突变损害了维持正常高尔基体结构和功能所需的驻留高尔基体蛋白的逆行流动，来解释COG突变的影响。
