保守寡聚高尔基体与神经元囊泡运输
Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking.
作者信息
Climer Leslie K, Hendrix Rachel D, Lupashin Vladimir V
机构信息
College of Medicine, Physiology and Biophysics, UAMS, Little Rock, AR, USA.
College of Medicine, Neurobiology and Developmental Sciences, UAMS, Little Rock, AR, USA.
出版信息
Handb Exp Pharmacol. 2018;245:227-247. doi: 10.1007/164_2017_65.
Abstract
The conserved oligomeric Golgi (COG) complex is an evolutionary conserved multi-subunit vesicle tethering complex essential for the majority of Golgi apparatus functions: protein and lipid glycosylation and protein sorting. COG is present in neuronal cells, but the repertoire of COG function in different Golgi-like compartments is an enigma. Defects in COG subunits cause alteration of Golgi morphology, protein trafficking, and glycosylation resulting in human congenital disorders of glycosylation (CDG) type II. In this review we summarize and critically analyze recent advances in the function of Golgi and Golgi-like compartments in neuronal cells and functions and dysfunctions of the COG complex and its partner proteins.
摘要
保守寡聚高尔基体（COG）复合体是一种进化上保守的多亚基囊泡拴系复合体，对大多数高尔基体功能至关重要：蛋白质和脂质糖基化以及蛋白质分选。COG存在于神经元细胞中，但COG在不同高尔基体样区室中的功能情况仍是个谜。COG亚基的缺陷会导致高尔基体形态、蛋白质运输和糖基化改变，从而引发II型人类先天性糖基化障碍（CDG）。在本综述中，我们总结并批判性地分析了高尔基体和高尔基体样区室在神经元细胞中的功能以及COG复合体及其伴侣蛋白的功能和功能障碍方面的最新进展。
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