Hauck Christof R, Ohlsen Knut
Zentrum für Infektionsforschung and Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Curr Opin Microbiol. 2006 Feb;9(1):5-11. doi: 10.1016/j.mib.2005.12.002. Epub 2006 Jan 6.
Staphylococcus aureus is a leading cause of hospital-acquired and often persistent infections. A key feature of pathogenic S. aureus is the expression of an array of extracellular matrix-binding proteins. In particular, the fibronectin-binding proteins FnBP-A and FnBP-B afford the pathogen the ability to connect to cellular integrins and to trigger internalization into host cells. Recent work has highlighted the role of host cell invasion in the pathogenesis of S. aureus, the structure-function relationship of FnBPs, and the host factors required to allow bacterial uptake. Understanding the invasive capacity of S. aureus should open up new avenues to control this microorganism in diverse disease settings.
金黄色葡萄球菌是医院获得性感染且常常是持续性感染的主要病因。致病性金黄色葡萄球菌的一个关键特征是一系列细胞外基质结合蛋白的表达。特别是，纤连蛋白结合蛋白FnBP - A和FnBP - B使病原体能够连接到细胞整合素并触发内化进入宿主细胞。最近的研究突出了宿主细胞侵袭在金黄色葡萄球菌发病机制中的作用、FnBPs的结构 - 功能关系以及允许细菌摄取所需的宿主因子。了解金黄色葡萄球菌的侵袭能力应该会为在不同疾病环境中控制这种微生物开辟新途径。
