Chiu Ya-Lin, Greene Warner C
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA.
J Biol Chem. 2006 Mar 31;281(13):8309-12. doi: 10.1074/jbc.R500021200. Epub 2005 Dec 30.
The field of human immunodeficiency virus (HIV) biology has been galvanized by the discovery of innate APOBEC3 cytidine deaminases, which pose powerful barriers to the replication of HIV and other retroviruses. Rapid progress has been made in defining their action, intriguing regulation within cells, expanded range of retroviral targets, and counterstrikes utilized by retroviruses against them. Although scientifically fascinating, advances in APOBEC3 biology may lead to new antiviral drugs and improved lentiviral vectors for gene therapy.
人类免疫缺陷病毒（HIV）生物学领域因天然载脂蛋白B mRNA编辑酶催化多肽样3（APOBEC3）胞苷脱氨酶的发现而受到推动，该酶对HIV和其他逆转录病毒的复制构成强大障碍。在确定其作用、细胞内有趣的调控、逆转录病毒靶标的扩大范围以及逆转录病毒针对它们的反击方面已经取得了迅速进展。尽管在科学上引人入胜，但APOBEC3生物学的进展可能会带来新的抗病毒药物和改进的用于基因治疗的慢病毒载体。
