Delis Spiros, Bakoyiannis Andreas, Giannakou Niki, Tsigka Alexia, Avgerinos Costas, Dervenis Christos
First Surgical Department, Hepato-Pancreatic Unit, Agia Olga Hospital, Athens, Greece.
JOP. 2006 Jan 11;7(1):70-3.
Pancreatic endocrine tumors are unusual tumors arising from cells belonging generically to the amine precursor uptake and decarboxylation system.
We present a case of a calcitonin-secreting pancreatic endocrine tumor in a 59-year-old male who presented at our Center with elevated calcitonin values. The patient was asymptomatic. Further investigation revealed a tumor, 80 mm in diameter, in the pancreatic body and tail along with three metastatic lesions in segments III, V, and VIII of the liver. Following a distal pancreatectomy, splenectomy and wedge resection of segments III and V along with radiofrequency ablation of the segment VIII lesion, his serum calcitonin reached normal values.
Calcitonin-secreting pancreatic endocrine tumors are often malignant and have a poor prognosis. We believe that an aggressive surgical approach may improve survival.
胰腺内分泌肿瘤是起源于一般属于胺前体摄取和脱羧系统细胞的罕见肿瘤。
我们报告一例59岁男性分泌降钙素的胰腺内分泌肿瘤，该患者因降钙素值升高就诊于我院。患者无症状。进一步检查发现胰体尾有一个直径80毫米的肿瘤，同时在肝的III、V和VIII段有三个转移病灶。在进行远端胰腺切除术、脾切除术以及III和V段楔形切除并对VIII段病灶进行射频消融后，患者血清降钙素恢复正常。
分泌降钙素的胰腺内分泌肿瘤通常为恶性，预后较差。我们认为积极的手术方法可能会提高生存率。
