Mullerpatan Prashant M, Joshi Shashank R, Shah Rajiv C, Tampi Chandralekha S, Doctor Vatsala M, Jagannath Palepu, Modlin Irvin
Department of Surgical Oncology, Lilavati Hospital and Research Centre, Bandra Reclamation, Bandra(W), Mumbai 400 050, India.
Dig Surg. 2004;21(4):321-4. doi: 10.1159/000080901. Epub 2004 Sep 17.
Pancreatic endocrine tumors (PETs) are unusual tumors arising from cells belonging generically to the amine precursor uptake and decarboxylation systems. We present a case of a calcitonin-secreting PET in a 56-year-old female who presented with watery diarrhea, dehydration and hypokalemia. Investigation revealed hypercalcemia, hyperphosphatemia, hypercalcitonemia and a well-defined mass in the head of the pancreas on CT scan. Following a pancreaticoduodenectomy her serum calcitonin levels returned to normal and diarrhea disappeared. The identification of this particularly rare presentation of a calcitonin-secreting PET provides the opportunity to examine this pathological entity within the context of the very few previously reported instances of this disease.
胰腺内分泌肿瘤（PETs）是一类罕见的肿瘤，起源于一般属于胺前体摄取和脱羧系统的细胞。我们报告一例56岁女性分泌降钙素的PET病例，该患者表现为水样腹泻、脱水和低钾血症。检查发现血钙过高、血磷过高、降钙素过高，CT扫描显示胰腺头部有一个边界清晰的肿块。胰十二指肠切除术后，她的血清降钙素水平恢复正常，腹泻消失。这种分泌降钙素的PET的特别罕见表现的发现，为在该疾病此前极少报道的病例背景下研究这一病理实体提供了机会。
