Bulygina V V, Amstislavskaia T G, Maslova L N
Ross Fiziol Zh Im I M Sechenova. 2005 Nov;91(11):1356-65.
The effects of chronic postweaning social isolation combined with subsequent resocialization on the sexual arousal were studied in male rats with inherited stress-induced arterial hypertension (ISIAH strain) and in Wistar rats. Young males were isolated on the Day 21 of postnatal life for 6 weeks. Then they were kept in groups of 5. 4-month males underwent the partition test: a receptive female was introduced into the male's cage, but the male and the female were separated by a transparent partition. The number of approaches to the partition and total time spent near the partition during the test served as an index of sexual motivation. Hormonal component of sexual arousal was estimated by measuring plasma testosterone level. No interstrain differences in magnitude of the sexual arousal were observed. However, chronic social isolation during juvenile period caused a genotype-dependent diminution of sexual motivation in the adult male rats of both strains. The decrease of sexual motivation in ISIAH rats was more pronounced as compared to Wistar rats. Moreover, the social isolation during the juvenile period completely abolished the female-induced rise in plasma testosterone in ISIAH and Wistar male rats. Plasma corticosterone level was increased during the period of sexual arousal, but this rise of corticosterone was not affected by the social conditions during postweaning period.
在患有遗传性应激诱导型动脉高血压的雄性大鼠（ISIAH品系）和Wistar大鼠中，研究了断奶后长期社会隔离并随后重新社会化对性唤起的影响。幼龄雄性大鼠在出生后第21天被隔离6周。然后将它们以每组5只的形式饲养。4月龄的雄性大鼠接受分隔测试：将一只处于接受状态的雌性大鼠放入雄性大鼠的笼子中，但雄性和雌性之间用透明隔板隔开。测试期间接近隔板的次数和在隔板附近花费的总时间用作性动机的指标。通过测量血浆睾酮水平来评估性唤起的激素成分。未观察到性唤起程度的品系间差异。然而，幼年时期的长期社会隔离导致两个品系成年雄性大鼠的性动机出现基因型依赖性降低。与Wistar大鼠相比，ISIAH大鼠的性动机下降更为明显。此外，幼年时期的社会隔离完全消除了雌性诱导的ISIAH和Wistar雄性大鼠血浆睾酮升高。在性唤起期间血浆皮质酮水平升高，但断奶后时期的社会条件并未影响这种皮质酮的升高。
