Amstislavskaya Tamara G, Bulygina Veta V, Tikhonova Maria A, Maslova Larissa N
Laboratory of Behavioral Neurogenomics, Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Lavrentyev Ave., 10, Novosibirsk 630090, Russia.
Chin J Physiol. 2013 Feb 28;56(1):36-43. doi: 10.4077/CJP.2013.BAA074.
Reproductive functions in adult organism are known to be affected by different factors. Effects of social environment at the postnatal ontogenesis attract particular attention since it has deep impact on the development of physiological and emotional state of an individual. Effects of chronic social isolation at different ages on male sexual motivation, testosterone and corticosterone response under conditions of sexual arousal were studied in Wistar rats. After weaning at the 21st [corrected] day of age, rats of one group were isolated for six weeks and after that they were housed in groups of five per cage for ten weeks (Iso3-9). Rats of the second group were housed in groups of five animals per cage till 13 weeks of age, and then they were isolated for six weeks (Iso13-19). Rats of the control group were housed in groups during the experiment. Adult 19 week- old male rats were tested under conditions of sexual arousal. The expression of sexual motivation was estimated as the behavioral activity of a male at the transparent perforated partition separating a receptive female. Isolation of adult male rats reduced the number of approaches to the partition, while the period of time a male spent at the partition was not changed and testosterone response was enhanced as compared to control rats. Chronic social isolation during peri-adolescence reduced sexual motivation and prevented arousal-induced elevation of testosterone. Plasma corticosterone increases at sexual arousal in the two groups of isolated rats did not differ from that in controls. Our results are evidence that social isolation during the post-maturity stage (Iso13-19) did not diminish the manifestation of sexual motivation and hormonal response to a receptive female, while isolation during peri-adolescence attenuated behavioral and hormonal expression of sexual arousal in adult males.
已知成年生物体的生殖功能会受到不同因素的影响。出生后个体发育过程中社会环境的影响备受关注，因为它对个体生理和情绪状态的发展有着深远影响。在Wistar大鼠中研究了不同年龄阶段慢性社会隔离对雄性性动机、睾酮和性唤起条件下皮质酮反应的影响。在21日龄[校正后]断奶后，一组大鼠被隔离6周，之后每笼5只分组饲养10周（Iso3 - 9）。第二组大鼠每笼5只分组饲养至13周龄，然后隔离6周（Iso13 - 19）。对照组大鼠在实验期间一直分组饲养。对19周龄成年雄性大鼠进行性唤起条件下的测试。性动机的表达通过雄性在分隔可接受雌性的透明穿孔隔板处的行为活动来评估。成年雄性大鼠的隔离减少了接近隔板的次数，而雄性在隔板处停留的时间未改变，并且与对照大鼠相比，睾酮反应增强。青春期前后的慢性社会隔离降低了性动机，并阻止了性唤起诱导的睾酮升高。两组隔离大鼠在性唤起时血浆皮质酮的增加与对照组无差异。我们的结果证明，成熟后期（Iso13 - 19）的社会隔离并未削弱对可接受雌性的性动机表现和激素反应，而青春期前后的隔离则减弱了成年雄性性行为和激素对性唤起的表达。
