Regnier Alain, Lemagne Capucine, Ponchet Alice, Cazalot Guillaume, Concordet Didier, Gelatt Kirk N
Department of Clinical Sciences, National Veterinary School, 31076 Toulouse, France.
Vet Ophthalmol. 2006 Jan-Feb;9(1):39-43. doi: 10.1111/j.1463-5224.2005.00435.x.
The current study was undertaken to evaluate the effects of topically applied bimatoprost, an ocular hypotensive lipid, on intraocular pressure (IOP) and pupil size (PS) in healthy cats.
Nine European Shorthair cats free from clinically relevant ocular abnormalities were used in the study.
Pretreatment baseline measurements of IOP and PS were obtained bilaterally at 8 am, 2 pm, and 8 pm for five consecutive days (days 1 to 5). Then the cats received one drop twice daily (10 am and 6 pm) of bimatoprost ophthalmic solution 0.03% (Lumigantrade mark, Allergan Inc., Irvine, CA USA), in one randomly selected eye and one drop of artificial tears in the fellow eye (control eye) for 5 days (days 6 to 10). Values for IOP and PS were obtained under the same conditions as in the pretreatment phase. The potential for ocular irritation following bimatoprost application was also evaluated.
During the pretreatment period, the mean IOP and mean PS were not significantly different between the eyes subsequently treated with bimatoprost and those subsequently determined as controls. During the treatment period, the mean IOP in bimatoprost-treated eyes was not significantly lower than in control eyes (14.2+/-2.3 vs. 14.5+/-2.8 mmHg). Mean IOP in control eyes was not significantly changed at any time during the study period. A marked reduction of PS was seen in all bimatoprost-treated eyes, but no other clinically relevant side effects were observed.
Twice daily topical applications of bimatoprost produced miosis but had no significant effect on IOP in healthy cats.
本研究旨在评估局部应用比马前列素（一种降眼压脂质）对健康猫眼压（IOP）和瞳孔大小（PS）的影响。
选用9只无临床相关眼部异常的欧洲短毛猫进行研究。
连续5天（第1天至第5天），于上午8点、下午2点和晚上8点双侧测量IOP和PS的预处理基线值。然后，猫在随机选择的一只眼中每天两次（上午10点和下午6点）滴入一滴0.03%的比马前列素滴眼液（商品名Lumigan，美国艾尔建公司，加利福尼亚州欧文市），在另一只眼中滴入一滴人工泪液（对照眼），持续5天（第6天至第10天）。在与预处理阶段相同的条件下获取IOP和PS值。还评估了应用比马前列素后眼部刺激的可能性。
在预处理期间，随后接受比马前列素治疗的眼睛与随后被确定为对照的眼睛之间，平均IOP和平均PS无显著差异。在治疗期间，比马前列素治疗眼的平均IOP并不显著低于对照眼（14.2±2.3 vs. 14.5±2.8 mmHg）。在研究期间，对照眼的平均IOP在任何时候均无显著变化。所有接受比马前列素治疗的眼睛均出现PS明显缩小，但未观察到其他临床相关副作用。
每天两次局部应用比马前列素可导致健康猫瞳孔缩小，但对眼压无显著影响。
