Bartoe Joshua T, Davidson Harriet J, Horton Mary T, Jung Yoonsung, Brightman Alan H
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan KS, USA.
Vet Ophthalmol. 2005 Jul-Aug;8(4):247-52. doi: 10.1111/j.1463-5224.2005.00397.x.
To evaluate the effects on intraocular pressure (IOP), pupillary diameter (PD), blepharospasm score, conjunctival injection score, and aqueous humor flare score when either 0.03% bimatoprost solution is applied once daily or 0.15% unoprostone isopropyl solution is applied twice daily topically to the eyes of normal cats.
The aforementioned parameters were evaluated daily in each of 12 cats throughout the entirety of the study. During an initial 10-day treatment phase a single eye of six of the cats was treated with 0.03% bimatoprost solution while a single eye of the remaining six cats was treated with buffered saline solution (BSS) once daily. During a second 10-day treatment phase a single eye of six of the cats was treated with 0.15% unoprostone isopropyl solution while a single eye of the remaining six cats was treated with BSS twice daily. Contralateral eyes of all cats remained untreated at all time points.
Blepharospasm score, conjunctival injection score, and aqueous humor flare score never rose from a value of 0, for any eye of any cat during the study. The mean +/- SD of IOP for eyes treated with 0.03% bimatoprost solution and BSS were 16.55 +/- 3.06 mmHg and 18.02 +/- 3.52 mmHg, respectively. The mean +/- of PD for eyes treated with 0.03% bimatoprost solution and BSS were 5.7 +/- 1.57 mm and 6.39 +/- 1.78 mm, respectively. The mean +/- SD of IOP for eyes treated with 0.15% unoprostone isopropyl solution and BSS were 15.7 +/- 2.91 mmHg and 17.2 +/- 2.9 mmHg, respectively. The mean +/- SD of PD for eyes treated with 0.15% unoprostone isopropyl solution and BSS were 5.8 +/- 1.43 mm and 6.9 +/- 1.37 mm, respectively. There was no significant difference (P > or = 0.05) in IOP or PD between eyes treated with 0.03% bimatoprost solution vs. eyes treated with BSS. Similarly, there was no significant difference (P > or = 0.05) in IOP or PD between eyes treated with 0.15% unoprostone isopropyl solution vs. eyes treated with BSS.
Neither once daily topical administration of 0.03% bimatoprost solution nor twice daily topical administration of 0.15% unoprostone isopropyl solution significantly affect the IOP of normal cats. Both 0.03% bimatoprost solution and 0.15% unoprostone isopropyl solution induced no significant ocular side effects in normal cats when dosed over a 10-day treatment period.
评估每天一次局部应用0.03%比马前列素溶液或每天两次局部应用0.15%异丙前列醇溶液对正常猫眼睛的眼压（IOP）、瞳孔直径（PD）、眼睑痉挛评分、结膜充血评分和房水闪光评分的影响。
在整个研究过程中，每天对12只猫的上述参数进行评估。在最初的10天治疗阶段，6只猫的一只眼睛每天用0.03%比马前列素溶液治疗，其余6只猫的一只眼睛每天用缓冲盐溶液（BSS）治疗。在第二个10天治疗阶段，6只猫的一只眼睛每天两次用0.15%异丙前列醇溶液治疗，其余6只猫的一只眼睛每天两次用BSS治疗。所有猫的对侧眼睛在所有时间点均未接受治疗。
在研究期间，任何猫的任何眼睛的眼睑痉挛评分、结膜充血评分和房水闪光评分从未从0分升高。用0.03%比马前列素溶液和BSS治疗的眼睛的IOP平均值±标准差分别为16.55±3.06 mmHg和18.02±3.52 mmHg。用0.03%比马前列素溶液和BSS治疗的眼睛的PD平均值±分别为5.7±1.57 mm和6.39±1.78 mm。用0.15%异丙前列醇溶液和BSS治疗的眼睛的IOP平均值±标准差分别为15.7±2.91 mmHg和17.2±2.9 mmHg。用0.15%异丙前列醇溶液和BSS治疗的眼睛的PD平均值±标准差分别为5.8±1.43 mm和6.9±1.37 mm。用0.03%比马前列素溶液治疗的眼睛与用BSS治疗的眼睛之间的IOP或PD无显著差异（P≥0.05）。同样，用0.15%异丙前列醇溶液治疗的眼睛与用BSS治疗的眼睛之间的IOP或PD无显著差异（P≥0.05）。
每天一次局部应用0.03%比马前列素溶液或每天两次局部应用0.15%异丙前列醇溶液均未显著影响正常猫的眼压。在10天的治疗期内给药时，0.03%比马前列素溶液和0.15%异丙前列醇溶液在正常猫中均未引起明显的眼部副作用。
