Dourmishev Assen L, Dourmishev Lyubomir A, Schwartz Robert A
Department of Dermatology and Venereology, Medical University, Sofia, Bulgaria.
Int J Dermatol. 2005 Dec;44(12):981-8. doi: 10.1111/j.1365-4632.2004.02253.x.
Ivermectin is a synthetic derivative of the antiparasitic class of compounds known as avermectins. It is a macrolide endectocide with activity against both endoparasites with cutaneous tropism (Strongyloides stercoralis, Ancylostoma braziliense, Cochliomyia hominivorax, Dermatobia hominis, Filaria bancrofti, Wucheria malayi, Onchocerca volvulus, Loa-loa) and ectoparasites such as Sarcoptes scabies, Pediculus humanus, Demodex folliculorum, and Cheyletiella sp. Ivermectin is of great interest in the treatment of patients with different forms of scabies, head lice, demodecidosis, cutaneous larva migrans, cutaneous larva currens, myiasis, and filariasis.
伊维菌素是一种被称为阿维菌素的抗寄生虫类化合物的合成衍生物。它是一种大环内酯类体内外寄生虫杀虫剂，对具有皮肤嗜性的体内寄生虫（粪类圆线虫、巴西钩虫、人皮蝇、人肤蝇、班氏丝虫、马来布鲁线虫、盘尾丝虫、罗阿丝虫）和体外寄生虫如疥螨、人虱、毛囊蠕形螨和犬小孢子菌均有活性。伊维菌素在治疗不同类型的疥疮、头虱、毛囊蠕形螨病、皮肤幼虫移行症、匐行疹、蝇蛆病和丝虫病患者方面具有重要意义。
