Laurence Arian D J
University College Hospital London, Grafton Way, London, UK.
Br J Haematol. 2006 Feb;132(3):255-67. doi: 10.1111/j.1365-2141.2005.05841.x.
Chemokines are a family of over 40 small (8 kDa) related proteins with the function of moving cells along a chemotactic gradient, either to organise cells within an organ or to facilitate the movement of leucocytes around the body. Mouse models have implicated the importance of the chemokine CXCL12 in haematopoiesis and this has lead to the use of the inhibitor AMD3100 for autologous transplantation. This review will briefly discuss the biology of chemokines and their role in haematopoiesis and haematological malignancy together with the possible benefits and hazards of therapeutic modification of the chemokine system.
趋化因子是一族超过40种的小（8千道尔顿）相关蛋白，其功能是使细胞沿着趋化梯度移动，要么在一个器官内组织细胞，要么促进白细胞在体内的移动。小鼠模型已表明趋化因子CXCL12在造血过程中的重要性，这已导致使用抑制剂AMD3100进行自体移植。本综述将简要讨论趋化因子的生物学特性及其在造血和血液系统恶性肿瘤中的作用，以及趋化因子系统治疗性修饰的可能益处和风险。
