Gronthos Stan, Zannettino Andrew C W
Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, South Australia, Australia.
Trends Endocrinol Metab. 2007 Apr;18(3):108-13. doi: 10.1016/j.tem.2007.02.002. Epub 2007 Feb 21.
The chemokine CXCL12 (variously termed stromal-derived factor 1 or B cell-stimulating factor) is a highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the postnatal organism. Although considered an important factor in normal bone metabolism, recent studies implicate CXCL12 in the pathogenesis of several diseases involving the skeleton, including rheumatoid arthritis and cancers that metastasize to bone. Recent studies have highlighted an emerging role for CXCL12 in the processes of physiological and pathological bone remodelling.
趋化因子CXCL12（又称基质衍生因子1或B细胞刺激因子）是一种高度保守的趋化性细胞因子，属于CXC趋化因子大家族。CXCL12在胚胎发育过程中多个器官系统的形成以及出生后机体骨髓造血和免疫功能的调节中发挥着关键作用。尽管CXCL12被认为是正常骨代谢中的一个重要因素，但最近的研究表明，它在包括类风湿性关节炎和骨转移癌在内的几种涉及骨骼的疾病的发病机制中也有牵连。最近的研究突出了CXCL12在生理和病理骨重塑过程中正在显现的作用。
