Griswold Cortland K
Department of Zoology, University of British Columbia, Vancouver, BC, Canada V6H 1Z4.
Evol Dev. 2006 Jan-Feb;8(1):81-93. doi: 10.1111/j.1525-142X.2006.05077.x.
The relationship between pleiotropy and the rate of evolution of a phenotypic character (evolvability) in a population is explored using computer simulations. I present results that suggest the rate of evolution of a phenotypic character may not decline when that character is pleiotropically associated to an increasing number of other characters, provided that the characters are under pure directional selection such that they are far from their optima relative to the average magnitude of a mutation. These conditions may be relevant during adaptive radiations. Adding pleiotropic associations to a set of characters in which one is under directional selection and the other is under stabilizing selection increases the rate of adaptation of the character under directional selection provided that the new characters that come to be pleiotropically associated are under directional selection. Thus, increasing the number of pleiotropic associations under these conditions increases the rate of adaptation of a character.
利用计算机模拟探索了群体中多效性与表型性状进化速率（可进化性）之间的关系。我展示的结果表明，当一个表型性状与越来越多的其他性状多效性相关时，该性状的进化速率可能不会下降，前提是这些性状处于纯定向选择之下，使得相对于突变的平均幅度而言，它们远离其最优值。这些条件在适应性辐射期间可能是相关的。在一组性状中，若其中一个处于定向选择而另一个处于稳定选择，增加多效性关联会提高处于定向选择的性状的适应速率，前提是新出现的多效性关联的性状也处于定向选择之下。因此，在这些条件下增加多效性关联的数量会提高一个性状的适应速率。
