Jenny N S, Arnold A M, Kuller L H, Sharrett A R, Fried L P, Psaty B M, Tracy R P
Department of Pathology, College of Medicine, University of Vermont, Burlington, VT, USA.
J Thromb Haemost. 2006 Jan;4(1):107-13. doi: 10.1111/j.1538-7836.2005.01678.x.
Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression.
We examined the association of sICAM-1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age > or = 65 years) from the Cardiovascular Health Study.
Selected participants were free of clinical CVD at baseline. Non-exclusive incident case groups were angina (n = 534), myocardial infarction (n = 304), stroke (n = 327), and death (n = 842; CVD death = 310). A total 643 subjects were free of events during follow-up.
sICAM-1 was positively associated with C-reactive protein, interleukin-6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM-1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM-1 (89.7 ng mL(-1)) were 1.3 (1.1-1.4) in men and 1.2 (1.1-1.3) in women. sICAM-1 was associated with increased risk of CVD death in women (1.2; 1.0-1.5), but not men (1.1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events.
While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women.
细胞间黏附分子-1（ICAM-1）调节白细胞与内皮细胞的黏附，这一过程对动脉粥样硬化至关重要。循环可溶性ICAM-1（sICAM-1）可能作为心血管疾病（CVD）进展的标志物。
我们在心血管健康研究中，研究了sICAM-1与老年男性和女性（年龄≥65岁）亚临床CVD指标以及CVD事件和死亡风险之间的关联。
入选参与者在基线时无临床CVD。非排他性的事件病例组包括心绞痛（n = 534）、心肌梗死（n = 304）、中风（n = 327）和死亡（n = 842；CVD死亡 = 310）。共有643名受试者在随访期间无事件发生。
在这些老年男性和女性中，sICAM-1与C反应蛋白、白细胞介素-6和纤维蛋白原以及亚临床CVD指标呈正相关。在根据年龄、性别和种族调整的Cox回归模型中，sICAM-1水平升高与男性和女性全因死亡率增加相关。sICAM-1每增加一个标准差（89.7 ng mL(-1)），男性的风险比（95%置信区间）为1.3（1.1 - 1.4），女性为1.2（1.1 - 1.3）。sICAM-1与女性CVD死亡风险增加相关（1.2；1.0 - 1.5），但与男性无关（1.1；0.9 - 1.3）。sICAM-1与非致命性CVD事件无关联。
虽然sICAM-1与老年男性和女性的死亡相关，但sICAM-1与女性CVD死亡之间的关联更为显著。
