Khosravi Mohammad Bagher, Khezri Sasan, Azemati Simin
Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Paediatr Anaesth. 2006 Jan;16(1):54-8. doi: 10.1111/j.1460-9592.2005.01740.x.
Prevention of postoperative pain in children is one of the most important objectives of the anesthesiologist. Preoperative ilioinguinal and iliohypogastric nerve blocks have been widely used to provide analgesia in children undergoing herniorrhaphy. Tramadol is an analgesic with micro-opioid and nonopioid activity. In this study we compared the usage of intravenous tramadol with ilioinguinal and iliohypogastric nerve blocks for control of post-herniorrhaphy pain in children aged 2-7 years.
Sixty patients were randomly allocated to two groups of thirty. One group received tramadol 1.5 mg.kg(-1) i.v. before induction of general anesthesia and the other had an ilioinguinal and iliohypogastric nerve block with 0.5% bupivacaine (0.25 ml.kg(-1)) before skin incision. We assessed pain using the Children's Hospital of Eastern Ontario Pain Scale and the Categorical Pain Scale.
At 1, 4 and 24 h after surgery the two groups had identical pain scores. At 2 and 3 h after surgery the tramadol group experienced significantly less pain (P < 0.05). The rescue drug for residual pain, was used equally in the two groups. None of the 60 patients had respiratory depression but the tramadol group patients were found to have more episodes of nausea and vomiting (P < 0.05).
We concluded that tramadol can have at least the same analgesic effect as that of ilioinguinal and iliohypogastric nerve blocks for post-herniorrhaphy pain in children, with even a superior effect at the time of maximal analgesia. We also highlight the troublesome side-effect of nausea and vomiting which brings into question the benefits of using this opioid that seems to lack respiratory depression.
预防儿童术后疼痛是麻醉医生最重要的目标之一。术前髂腹股沟神经和髂腹下神经阻滞已广泛用于为接受疝修补术的儿童提供镇痛。曲马多是一种具有微阿片类和非阿片类活性的镇痛药。在本研究中,我们比较了静脉注射曲马多与髂腹股沟神经和髂腹下神经阻滞对2至7岁儿童疝修补术后疼痛的控制效果。
60例患者随机分为两组,每组30例。一组在全身麻醉诱导前静脉注射曲马多1.5mg·kg⁻¹,另一组在皮肤切口前用0.5%布比卡因(0.25ml·kg⁻¹)进行髂腹股沟神经和髂腹下神经阻滞。我们使用安大略东部儿童医院疼痛量表和分类疼痛量表评估疼痛。
术后1、4和24小时两组疼痛评分相同。术后2和3小时,曲马多组疼痛明显减轻(P<0.05)。两组用于缓解残余疼痛的急救药物使用情况相同。60例患者均无呼吸抑制,但发现曲马多组患者恶心呕吐发作更多(P<0.05)。
我们得出结论,曲马多在控制儿童疝修补术后疼痛方面至少与髂腹股沟神经和髂腹下神经阻滞具有相同的镇痛效果,在最大镇痛时甚至效果更佳。我们还强调了恶心呕吐这一麻烦的副作用,这让人质疑使用这种似乎无呼吸抑制作用的阿片类药物的益处。