Lash Timothy L, Fox Matthew P, Silliman Rebecca A
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Breast J. 2006 Jan-Feb;12(1):2-6. doi: 10.1111/j.1075-122X.2006.00177.x.
Guidelines have been developed for appropriate posttherapy surveillance for breast cancer recurrence. One purpose of posttherapy surveillance is to detect potentially curable local recurrences and new cancers in the opposite breast. The objective of this investigation was to assess the impact of annual mammography on all-cause mortality in breast cancer survivors. We conducted a case-control analysis nested in a cohort of 865 stage I or II breast cancer patients diagnosed from 1996 to 1999. The exposure variable was the number of mammograms received after completing primary therapy. Cases were decedents and we used risk-set sampling to match eight controls to each case on follow-up time. The mortality rate declined with an increasing number of mammograms (p for trend=0.007). The age- and therapy-adjusted odds ratio associating receipt of an additional mammogram, compared with receipt of no mammogram, equaled 0.77 (95% confidence interval [CI] 0.53-1.1). These results are consistent with a protective effect of regular surveillance mammography after completing therapy for early stage breast cancer.
已制定了乳腺癌复发后适当监测的指南。治疗后监测的一个目的是检测对侧乳房中可能可治愈的局部复发和新发癌症。本研究的目的是评估每年进行乳房X线检查对乳腺癌幸存者全因死亡率的影响。我们在一组1996年至1999年诊断的865例I期或II期乳腺癌患者中进行了病例对照分析。暴露变量是完成初始治疗后接受乳房X线检查的次数。病例为死亡者，我们使用风险集抽样，按照随访时间为每个病例匹配8名对照。死亡率随着乳房X线检查次数的增加而下降（趋势p=0.007）。与未接受乳房X线检查相比，接受额外一次乳房X线检查的年龄和治疗调整后的优势比为0.77（95%置信区间[CI]0.53-1.1）。这些结果与早期乳腺癌治疗后定期进行监测性乳房X线检查的保护作用一致。
