Fu Yi, Wei Xin, Ni Pei-hua, Ying Ya-yun, Song Yan-yan, Chen Sheng-di
Department of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
Zhonghua Nei Ke Za Zhi. 2005 Dec;44(12):914-7.
To investigate the relationship among beta-fibrinogen (Fg) concentration, related gene polymorphisms (including -148C/T, -249C/T, -455G/A, 448G/A, 1689T/G) and cerebral infarction.
Fg level and its five gene polymorphisms were analyzed with by polymerase chain reaction-restriction fragment length polymorphism in 132 patients with cerebral infarction, 79 patients with other neurological diseases and 92 healthy elders.
The plasma Fg level in cerebral infarction patients was significantly higher than that in the patients with other neurological diseases or healthy elders (P < 0.05). In the three groups, the plasma Fg levels in individuals with T-148 and A-455 alleles were higher than those in individuals without T-148 and A-455 alleles (P < 0.05). However, there were no statistically significant differences in the genotype and allele frequencies in the five mutation gene polymorphisms among the three groups (P > 0.05).
Cerebral infarction is a multifactorial disease and an increased Fg level is a risk factor for cerebral infarction. T-148 and A-455 allele can lead to elevated Fg concentration.
探讨β-纤维蛋白原（Fg）浓度、相关基因多态性（包括-148C/T、-249C/T、-455G/A、448G/A、1689T/G）与脑梗死之间的关系。
采用聚合酶链反应-限制性片段长度多态性方法，对132例脑梗死患者、79例其他神经系统疾病患者和92例健康老年人进行Fg水平及其5种基因多态性分析。
脑梗死患者血浆Fg水平显著高于其他神经系统疾病患者或健康老年人（P < 0.05）。在三组中，携带T-148和A-455等位基因个体的血浆Fg水平高于不携带T-148和A-455等位基因的个体（P < 0.05）。然而，三组间5种突变基因多态性的基因型和等位基因频率差异无统计学意义（P > 0.05）。
脑梗死是一种多因素疾病，Fg水平升高是脑梗死的危险因素。T-148和A-455等位基因可导致Fg浓度升高。
