Libíková H
Adv Exp Med Biol. 1975;53:469-79. doi: 10.1007/978-1-4757-0731-1_40.
Cells from leucosis-free chick embryos (skin and muscles), grown in vitro 1 and 7 days with no medium change, are used as a model for young dividing and stationary in vitro aged cells, respectively. Aged cultures are advantageous for IF induction by cytopathic and noncytopathic viruses. Decreased virus production in them is ascribed to a back effect of the early formed IF onto the inducing virus. A factor which stimulates viral IF interferon induction also in young cultures, is released from aged cells into the medium. This factor could belong -- according to its properties and action -- into the class of chalones.
来自无白血病鸡胚（皮肤和肌肉）的细胞，分别在体外培养1天和7天且不更换培养基，用作体外年轻分裂细胞和静止老化细胞的模型。老化培养物有利于细胞病变和非细胞病变病毒诱导产生干扰素。它们中病毒产量的降低归因于早期形成的干扰素对诱导病毒的反向作用。一种在年轻培养物中也能刺激病毒干扰素诱导的因子，从老化细胞释放到培养基中。根据其特性和作用，这种因子可能属于抑素类。
