Zilversmit D B
Am J Cardiol. 1975 Apr;35(4):559-66. doi: 10.1016/0002-9149(75)90840-1.
The rate of cholesterol accumulation is a function of three separate processes: the transfer of lipid or lipoprotein from blood plasma to the artery, the binding and sequestering of lipids in the arterial wall and the solubilization and removal of lipid from the artery. These processes have been studied with lipids or lipoproteins labeled with radioisotopes by autoradiographic and quantitative chemical procedures. More recently immunochemical procedures have been applied to this problem. Studies have been performed with intact animals, isolated organs and cell cultures. In addition, homogenates have been used successfully to study intraarterial transformations of lipids, (for example, cholesterol esterification). Although epidemiologic and clinical studies, as well as animal experiments, have provided evidence that the concentration of plasma low or very low density lipoproteins parallels the rate of atherogenesis, the nature of the causal chain linking plasma lipoproteins to atherosclerosis is as yet unclear. A possible link between plasma lipoproteins, arterial liproprotein lipase and atherogenesis has been postulated.
脂质或脂蛋白从血浆转移至动脉、脂质在动脉壁中的结合与隔离，以及脂质从动脉中的溶解和清除。这些过程已通过放射自显影和定量化学方法，对用放射性同位素标记的脂质或脂蛋白进行了研究。最近，免疫化学方法也已应用于这个问题。研究已在完整动物、离体器官和细胞培养物上进行。此外，匀浆已成功用于研究动脉内脂质的转化（例如，胆固醇酯化）。尽管流行病学和临床研究以及动物实验已提供证据表明血浆低密度或极低密度脂蛋白的浓度与动脉粥样硬化的发生率平行，但将血浆脂蛋白与动脉粥样硬化联系起来的因果链的本质仍不清楚。血浆脂蛋白、动脉脂蛋白脂肪酶与动脉粥样硬化之间的可能联系已被提出。
