Marshall G A, Shchelchkov E, Kaufer D I, Ivanco L S, Bohnen N I
Department of Neurology, University of Pittsburgh and Veterans Affairs Medical Center, Pittsburgh, PA, USA.
Acta Neurol Scand. 2006 Feb;113(2):87-91. doi: 10.1111/j.1600-0404.2005.00553.x.
To investigate the relationship between the severity of white matter hyperintensities (WMH) and cortical acetylcholinesterase (AChE) activity in parkinsonian dementia (PDem).
PDem (n = 11) and control subjects (n = 14) underwent [11C]methyl-4-piperidinyl propionate (11C-PMP) AChE brain positron emission tomography and magnetic resonance (MR) imaging. Presence of WMH on proton density and T2 MR images was scored using a modified version of the semi-quantitative rating scale by Scheltens et al. [J Neurol Sci114 (1993)].
Analysis demonstrated significantly lower mean cortical (11)C-PMP k3 hydrolysis rates in PDem (-19.9%) when compared with control subjects (P < 0.0001). PDem subjects had higher mean severity of WMH (+20.1%) when compared with control subjects (P < 0.05). When WMH severity was entered into the analysis of variance model, there was no significant co-variate effect on cortical AChE activity (F = 0.24, ns).
The concomitant presence of mild to moderate WMH in patients with PDem does not have a significant effect on cortical AChE activity.
探讨帕金森病痴呆（PDem）患者脑白质高信号（WMH）严重程度与皮质乙酰胆碱酯酶（AChE）活性之间的关系。
对11例PDem患者和14例对照者进行了[11C]甲基-4-哌啶丙酸酯（11C-PMP）AChE脑正电子发射断层扫描及磁共振（MR）成像。采用Scheltens等人[《神经病学杂志》114（1993）]半定量评分量表的改良版对质子密度和T2加权MR图像上WMH的存在情况进行评分。
分析表明，与对照者相比，PDem患者的平均皮质（11）C-PMP k3水解率显著降低（-19.9%）（P<0.0001）。与对照者相比，PDem患者的WMH平均严重程度更高（+20.1%）（P<0.05）。当将WMH严重程度纳入方差分析模型时，对皮质AChE活性无显著协变量效应（F = 0.24，无统计学意义）。
PDem患者中轻度至中度WMH的并存对皮质AChE活性无显著影响。
