Ghandehari K, Moud Z Izadi
Neurology Division, Southern Khorasan University of Medical Sciences, Southern Khorasan, Iran.
Acta Neurol Scand. 2006 Feb;113(2):121-4. doi: 10.1111/j.1600-0404.2005.00515.x.
Stroke in young adults causes morbidity in this socioeconomically active age group. The etiologic frequency of ischemic stroke in young adults differs around the world.
The study population consisted of 314,000 'young adult' residents in Southern Khorasan province in Iran. All patients with stroke are routinely admitted to the Valie Asr tertiary care hospital. Data on patients demographics, clinical presentation and investigations of consecutive patients aged 15-45 years with ischemic stroke are registered in Southern Khorasan stroke data bank for the period March 2000 to March 2005. All patients underwent a standard battery of diagnostic investigations by a stroke neurologist. The etiologic classification of stroke in the patients was made based on the trial of ORG 10172 in acute stroke treatment (TOAST) criteria.
One hundred and twenty-four patients (60 female, 64 male) were prospectively investigated during a 5-year period. The incidence of ischemic stroke in young adults was eight cases per 100,000 people per year. Cardioembolic mechanism comprised 54% of stroke etiology in young adults. Rheumatic valvular disease was present in 32% of the patients and caused 2.5 preventable stroke cases per 100,000 'young adults' per year.
Rheumatic valvular disease is the most common cause and a preventable etiology of stroke in Persian young adults.
年轻成年人中风会导致这个具有社会经济活动能力的年龄组出现发病情况。世界各地年轻成年人缺血性中风的病因频率有所不同。
研究人群包括伊朗霍拉桑省南部的31.4万名“年轻成年人”居民。所有中风患者均常规入住瓦利·阿斯尔三级护理医院。2000年3月至2005年3月期间，15至45岁缺血性中风连续患者的人口统计学数据、临床表现和检查数据被登记在霍拉桑省南部中风数据库中。所有患者均由中风神经科医生进行了一系列标准诊断检查。根据急性中风治疗中ORG 10172试验（TOAST）标准对患者中风进行病因分类。
在5年期间对124名患者（60名女性，64名男性）进行了前瞻性研究。年轻成年人缺血性中风的发病率为每年每10万人中有8例。心脏栓塞机制占年轻成年人中风病因的54%。32%的患者存在风湿性瓣膜病，每年每10万名“年轻成年人”中导致2.5例可预防的中风病例。
风湿性瓣膜病是波斯年轻成年人中风最常见的病因且是可预防的病因。
