细胞视黄醇结合蛋白在视黄酸代谢调节中发挥作用。
Cellular retinol-binding protein functions in the regulation of retinoid metabolism.
作者信息
Wolf G
机构信息
Department of Nutritional Sciences, University of California, Berkeley 94720.
出版信息
Nutr Rev. 1992 Jul;50(7):197-9. doi: 10.1111/j.1753-4887.1992.tb01325.x.
Abstract
A microsomal retinyl ester hydrolase from rat tissues is activated by apo-cellular retinol-binding protein, which thus regulates the availability of retinol either for binding to serum retinol-binding protein or for metabolic oxidation. Microsomal retinal synthesis was found to occur in rat tissues with holo-cellular retinol-binding protein as substrate. Retinal could be further oxidized to retinoic acid by a cytosolic fraction.
摘要
大鼠组织中的一种微粒体视黄酯水解酶可被脱辅基细胞视黄醇结合蛋白激活，从而调节视黄醇与血清视黄醇结合蛋白结合或进行代谢氧化的可用性。发现以全细胞视黄醇结合蛋白为底物时，大鼠组织中会发生微粒体视黄醛合成。视黄醛可被胞质部分进一步氧化为视黄酸。
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