Burdick Katherine E, Lencz Todd, Funke Birgit, Finn Christine T, Szeszko Philip R, Kane John M, Kucherlapati Raju, Malhotra Anil K
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA.
Hum Mol Genet. 2006 May 15;15(10):1563-8. doi: 10.1093/hmg/ddi481. Epub 2006 Jan 13.
Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.
人类智力是一种已知受遗传因素显著影响的特质，最近的连锁数据提供了定位证据，表明6号染色体短臂上一个先前与精神分裂症相关的区域可能与智力变异有关。dysbindin-1（DTNBP1）基因位于6号染色体短臂，也与精神分裂症有关，精神分裂症是一种以认知功能障碍为特征的神经精神疾病。我们在两个独立队列中报告了DTNBP1基因型与一般认知能力（g）之间的关联，其中包括213例精神分裂症或分裂情感性障碍患者以及126名健康志愿者。这些数据表明DTNBP1基因变异会影响人类智力。
