DTNBP1基因类型影响精神分裂症患者的认知衰退。
DTNBP1 genotype influences cognitive decline in schizophrenia.
作者信息
Burdick Katherine E, Goldberg Terry E, Funke Birgit, Bates John A, Lencz Todd, Kucherlapati Raju, Malhotra Anil K
机构信息
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, NY 11004, United States.
出版信息
Schizophr Res. 2007 Jan;89(1-3):169-72. doi: 10.1016/j.schres.2006.09.008. Epub 2006 Oct 30.
OBJECTIVE
Intellectual decline is common in schizophrenia and predicts functional outcome. While many patients undergo intellectual decline that typically predates the onset of symptoms, few studies have investigated the underlying mechanism through which this occurs. The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1).
METHODS
We assessed cognitive decline in 183 Caucasian patients with schizophrenia using a proxy measure of premorbid IQ with which current general cognitive ability (g) was compared. We then tested for a relationship between the risk haplotype identified in previous work (CTCTAC) and intellectual decline.
RESULTS
We found that carriers of the CTCTAC haplotype, demonstrated a significantly greater decline in IQ as compared with non-carriers (p=0.05).
CONCLUSIONS
These data suggest that DTNBP1 influences the severity of intellectual decline in schizophrenia and may represent one underlying cause for heterogeneity in cognitive course.
目的
智力衰退在精神分裂症中很常见，且可预测功能结局。虽然许多患者在症状出现之前就经历了智力衰退，但很少有研究调查其发生的潜在机制。本研究评估了精神分裂症患者智力衰退与dysbindin-1（DTNBP1）基因变异之间的关系。
方法
我们使用病前智商的替代指标评估了183名白种人精神分裂症患者的认知衰退情况，并与当前的一般认知能力（g）进行了比较。然后，我们测试了先前研究中确定的风险单倍型（CTCTAC）与智力衰退之间的关系。
结果
我们发现，与非携带者相比，CTCTAC单倍型携带者的智商下降更为显著（p = 0.05）。
结论
这些数据表明，DTNBP1会影响精神分裂症患者智力衰退的严重程度，可能是认知过程异质性的一个潜在原因。
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