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本文引用的文献

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Neurocognition as a stable endophenotype in bipolar disorder and schizophrenia.神经认知作为双相情感障碍和精神分裂症的一种稳定内表型
J Nerv Ment Dis. 2006 Apr;194(4):255-60. doi: 10.1097/01.nmd.0000207360.70337.7e.
2
An update on the genetics of schizophrenia.精神分裂症遗传学的最新进展。
Curr Opin Psychiatry. 2006 Mar;19(2):158-64. doi: 10.1097/01.yco.0000214341.52249.59.
3
Cognitive development in schizophrenia: follow-back from the first episode.精神分裂症的认知发展：首次发作后的追溯研究
J Clin Exp Neuropsychol. 2006 Feb;28(2):270-82. doi: 10.1080/13803390500360554.
4
Genetic variation in DTNBP1 influences general cognitive ability.DTNBP1基因的遗传变异会影响一般认知能力。
Hum Mol Genet. 2006 May 15;15(10):1563-8. doi: 10.1093/hmg/ddi481. Epub 2006 Jan 13.
5
Elaboration on premorbid intellectual performance in schizophrenia: premorbid intellectual decline and risk for schizophrenia.关于精神分裂症病前智力表现的阐述：病前智力衰退与精神分裂症风险
Arch Gen Psychiatry. 2005 Dec;62(12):1297-304. doi: 10.1001/archpsyc.62.12.1297.
6
Association of the DTNBP1 locus with schizophrenia in a U.S. population.DTNBP1基因座与美国人群精神分裂症的关联。
Am J Hum Genet. 2004 Nov;75(5):891-8. doi: 10.1086/425279. Epub 2004 Sep 10.
7
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia.精神分裂症易感基因失调结合蛋白的新型神经元功能证据。
Hum Mol Genet. 2004 Nov 1;13(21):2699-708. doi: 10.1093/hmg/ddh280. Epub 2004 Sep 2.
8
Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain.人类失调结合蛋白（DTNBP1）基因在正常大脑以及精神分裂症患者前额叶皮质和中脑中的表达。
Arch Gen Psychiatry. 2004 Jun;61(6):544-55. doi: 10.1001/archpsyc.61.6.544.
9
Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1).在两个独立样本中鉴定出肌萎缩蛋白结合蛋白基因（DTNBP1）的一种新型精神分裂症风险单倍型。
Arch Gen Psychiatry. 2004 Apr;61(4):336-44. doi: 10.1001/archpsyc.61.4.336.
10
A population-based cohort study of premorbid intellectual, language, and behavioral functioning in patients with schizophrenia, schizoaffective disorder, and nonpsychotic bipolar disorder.一项基于人群的队列研究，涉及精神分裂症、分裂情感性障碍和非精神病性双相情感障碍患者病前的智力、语言和行为功能。
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DTNBP1基因类型影响精神分裂症患者的认知衰退。

DTNBP1 genotype influences cognitive decline in schizophrenia.

作者信息

Burdick Katherine E, Goldberg Terry E, Funke Birgit, Bates John A, Lencz Todd, Kucherlapati Raju, Malhotra Anil K

机构信息

Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, NY 11004, United States.

出版信息

Schizophr Res. 2007 Jan;89(1-3):169-72. doi: 10.1016/j.schres.2006.09.008. Epub 2006 Oct 30.

DOI:10.1016/j.schres.2006.09.008
PMID:17074466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1828039/
Abstract

OBJECTIVE

Intellectual decline is common in schizophrenia and predicts functional outcome. While many patients undergo intellectual decline that typically predates the onset of symptoms, few studies have investigated the underlying mechanism through which this occurs. The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1).

METHODS

We assessed cognitive decline in 183 Caucasian patients with schizophrenia using a proxy measure of premorbid IQ with which current general cognitive ability (g) was compared. We then tested for a relationship between the risk haplotype identified in previous work (CTCTAC) and intellectual decline.

RESULTS

We found that carriers of the CTCTAC haplotype, demonstrated a significantly greater decline in IQ as compared with non-carriers (p=0.05).

CONCLUSIONS

These data suggest that DTNBP1 influences the severity of intellectual decline in schizophrenia and may represent one underlying cause for heterogeneity in cognitive course.

摘要

目的

智力衰退在精神分裂症中很常见，且可预测功能结局。虽然许多患者在症状出现之前就经历了智力衰退，但很少有研究调查其发生的潜在机制。本研究评估了精神分裂症患者智力衰退与dysbindin-1（DTNBP1）基因变异之间的关系。

方法

我们使用病前智商的替代指标评估了183名白种人精神分裂症患者的认知衰退情况，并与当前的一般认知能力（g）进行了比较。然后，我们测试了先前研究中确定的风险单倍型（CTCTAC）与智力衰退之间的关系。

结果

我们发现，与非携带者相比，CTCTAC单倍型携带者的智商下降更为显著（p = 0.05）。

结论

这些数据表明，DTNBP1会影响精神分裂症患者智力衰退的严重程度，可能是认知过程异质性的一个潜在原因。