Munkholm P, Langholz E, Nielsen O H, Kreiner S, Binder V
Dept. of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark.
Scand J Gastroenterol. 1992 Jul;27(7):609-14. doi: 10.3109/00365529209000127.
The incidence of Crohn's disease increased sixfold from 1962 to 1987 in the county of Copenhagen. The mean annual incidence for 1979-87 was 4.1 per 10(5) inhabitants. The increase was found equally in both sexes, with an approximately 40% higher incidence in women. The maximal incidence was found in the 15- to 24-year age group, being 12.8 per 10(5) per year for women and 6.0 per 10(5) per year for men, as mean of the period 1979-87. The prevalence at the end of the study was 54 per 10(5) inhabitants, 46 per 10(5) in men and 63 per 10(5) in women. The clinical appearance of the disease at the time of diagnosis was remarkably similar during the study period with regard to both the localization of disease and the clinical symptoms and signs. A slightly higher percentage of the patients, however, were in high disease activity at diagnosis in the later years of the study.
1962年至1987年间，哥本哈根郡克罗恩病的发病率增长了六倍。1979 - 1987年的年平均发病率为每10万居民4.1例。男女发病率增长情况相同，女性发病率约高40%。最高发病率出现在15至24岁年龄组，1979 - 1987年期间，女性每年每10万居民中有12.8例，男性为每年每10万居民中有6.0例。研究结束时的患病率为每10万居民54例，男性为每10万居民46例，女性为每10万居民63例。在研究期间，疾病诊断时的临床表现，无论是疾病的定位还是临床症状和体征，都非常相似。然而，在研究后期诊断时处于高疾病活动状态的患者比例略高。
