Bengone-Ndong T, Ba M A, Kane Y, Sané I, Sutra J F, Alvinerie M
Ecole Inter-Etats des Sciences et Médecine Vétérinaires, BP 5077, Dakar Fann, Sénégal.
Parasitol Res. 2006 May;98(6):501-6. doi: 10.1007/s00436-005-0103-x. Epub 2006 Jan 14.
The pharmacokinetics and mammary excretion of eprinomectin were determined in zebu Gobra following topical administration of 0.5 mg kg(-1). The kinetics of plasma and milk was analysed using a one-compartment model. The maximum plasma concentration of 8.83+/-2.15 ng ml(-1) occurred 1.30 days post-administration. The area under the plasma concentration-time curve was 30.63+/-5.56 ng day(-1) ml(-1) and the mean residence time was 3.38+/-0.60 days. Eprinomectin was detected in milk at the first sampling time and thereafter for at least 8 days. The systemic availability of eprinomectin was significantly lower than that for other breeds of cattle. Comparison of the milk and plasma data demonstrated the parallel disposition of the drug in the milk and plasma with a milk/plasma ratio of 0.094. The very low extent of mammary excretion supports the permitted use of eprinomectin in lactating zebu Gobra.
在对泽布戈布拉牛局部施用0.5毫克/千克的伊维菌素后，测定了其药代动力学和乳腺排泄情况。使用单室模型分析血浆和乳汁的动力学。给药后1.30天出现最大血浆浓度，为8.83±2.15纳克/毫升。血浆浓度-时间曲线下面积为30.63±5.56纳克·天⁻¹·毫升⁻¹，平均驻留时间为3.38±0.60天。在首次采样时在乳汁中检测到伊维菌素，此后至少8天均能检测到。伊维菌素的全身可用性显著低于其他品种的牛。乳汁和血浆数据的比较表明，药物在乳汁和血浆中的处置呈平行关系，乳汁/血浆比为0.094。极低的乳腺排泄程度支持在泌乳的泽布戈布拉牛中允许使用伊维菌素。
