Thaler Millard P, Ubogy Zeena I
Papillon Cosmetic Dermatology Center, Mesa, Arizona, USA.
Dermatol Surg. 2005 Nov;31(11 Pt 2):1566-74; discussion 1575-6. doi: 10.2310/6350.2005.31243.
Artefill is one of several new materials being introduced to the U.S. market as a soft tissue augmenting agent.
The objectives were to evaluate the safety and efficacy of injecting Artecoll (Rofil Medical International Breda, the Netherlands) in facial wrinkles compared with injecting Zyderm or Zyplast (INAMED, Santa Barbara, CA, USA) and discuss the practical lessons learned.
Thirty-eight patients were randomly selected to receive Artecoll or Zyderm/Zyplast into facial defects. Wrinkles were evaluated by the treating physician, the subject, and masked physician evaluators. Similar evaluations were performed on several collagen patients crossing over to Artecoll. Adverse reactions were recorded. RESULTS. All evaluators felt Artecoll to be superior to collagen in all treated areas except for the glabella and upper lip lines. In these areas, differentiation by photographs between the two products became more difficult for the masked evaluators. The adverse side effects of Artecoll were almost equal with those of collagen, but most were of minimal consequence. Three patients developed persistent nodules (all in perioral sites), which were treatable with intralesional steroids. CONCLUSION. Artecoll treatment of wrinkles and folds was found to be effective, long lasting, safe, and associated with a high percentage of patient acceptance. There is a learning curve in injecting this thicker, more permanent product.
Artefill是作为软组织填充剂被引入美国市场的几种新材料之一。
目的是评估注射Artecoll（荷兰布雷达罗菲尔国际医疗公司）治疗面部皱纹与注射Zyderm或Zyplast（美国加利福尼亚州圣巴巴拉市INAMED公司）相比的安全性和有效性，并讨论所获得的实际经验教训。
随机选择38例患者，将Artecoll或Zyderm/Zyplast注射到面部缺损处。由治疗医生、受试者和盲法医生评估者对面部皱纹进行评估。对转而使用Artecoll的几名胶原蛋白治疗患者进行了类似评估。记录不良反应。结果。所有评估者均认为，除眉间和上唇纹外，在所有治疗区域Artecoll均优于胶原蛋白。在这些区域，对于盲法评估者而言，通过照片区分这两种产品变得更加困难。Artecoll的不良反应与胶原蛋白的几乎相同，但大多数后果轻微。3例患者出现持续性结节（均位于口周部位），可通过病灶内注射类固醇进行治疗。结论。发现Artecoll治疗皱纹和褶皱有效、持久、安全，且患者接受率高。注射这种更浓稠、更持久的产品存在一个学习曲线。
