意大利一家医院中糖肽类药物使用的合理性

Appropriateness of glycopeptide use in a hospital in Italy.

作者信息

Bianco Aida, Rizza Paolo, Scaramuzza Gaetano, Pavia Maria

机构信息

Chair of Hygiene, Medical School, University of Catanzaro Magna Graecia, Via Tommaso Campanella, 88100 Catanzaro, Italy.

出版信息

Int J Antimicrob Agents. 2006 Feb;27(2):113-9. doi: 10.1016/j.ijantimicag.2005.10.004. Epub 2006 Jan 18.

DOI:10.1016/j.ijantimicag.2005.10.004

PMID:16417993

Abstract

The aims of this study were to quantify the rate of inappropriate glycopeptide use. The study was carried out by reviewing all medical records of patients who received a glycopeptide in a hospital located in Italy. A total of 452 patients received glycopeptides, with a rate of inappropriate use of 90.9%. Appropriateness of glycopeptide prescriptions was significantly higher in Intensive Care Units compared with surgical wards (odds ratio (OR) = 0.03; 95% confidence interval (CI) = 0.01-0.14), in younger patients (OR = 0.97; 95% CI = 0.95-0.99) and in those patients who received the prescription for therapy rather than prophylaxis (OR = 0.2; 95% CI = 0.06-0.66). Models were also developed to predict appropriateness of glycopeptide indications for therapy and prophylaxis. The information obtained in our audit may enable development of strategies to improve physician prescribing patterns.

摘要

本研究的目的是量化糖肽类药物不适当使用的比率。该研究通过查阅意大利一家医院中所有接受糖肽类药物治疗的患者的病历进行。共有452名患者接受了糖肽类药物治疗，不适当使用率为90.9%。与外科病房相比，重症监护病房中糖肽类药物处方的适当性显著更高（优势比（OR）=0.03；95%置信区间（CI）=0.01 - 0.14），在年轻患者中（OR = 0.97；95% CI = 0.95 - 0.99）以及在接受治疗而非预防处方的患者中（OR = 0.2；95% CI = 0.06 - 0.66）也是如此。还建立了模型来预测糖肽类药物治疗和预防指征的适当性。我们审计中获得的信息可能有助于制定改善医生处方模式的策略。