Omran M A, Abdel-Rahman M S, Nabil Z I
Pharmacology and Toxicology Department, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103-2714.
Toxicol Lett. 1992 Jul;61(2-3):175-84. doi: 10.1016/0378-4274(92)90144-9.
The effects of the scorpion Leiurus quinquestriatus (H.&E.) venom on electrocardiogram (ECG) parameters such as P-R and Q-T intervals and R and T wave amplitudes were investigated in anesthetized rats. Venom was administered intramuscularly (i.m.) at three doses (100, 200 and 400 micrograms/kg). ECG limb lead II was recorded for 4-h sessions. Because autonomic nervous system tone plays an important role in influencing ECG findings, another study was completed with concomitant pharmacologic autonomic nervous system blockade. Propranolol or atropine was injected 20 min before venom administration in two groups of rats. The results indicated that the venom has drastic effects on the electrical activity of the heart. The Q-T interval developed a dose-response relationship after venom administration. Propranolol abolished the toxic effects of the venom on P-R and Q-T intervals as well as on R wave amplitude, while atropine had no effect on the ECG changes produced by the venom.
研究了以色列金蝎（H.&E.）毒液对麻醉大鼠心电图（ECG）参数（如P-R和Q-T间期以及R波和T波振幅）的影响。毒液以三种剂量（100、200和400微克/千克）进行肌肉注射（i.m.）。记录ECG肢体导联II 4小时。由于自主神经系统张力在影响ECG结果方面起着重要作用，因此进行了另一项伴随药理学自主神经系统阻断的研究。在两组大鼠中，在毒液给药前20分钟注射普萘洛尔或阿托品。结果表明，毒液对心脏电活动有剧烈影响。毒液给药后，Q-T间期呈现剂量反应关系。普萘洛尔消除了毒液对P-R和Q-T间期以及R波振幅的毒性作用，而阿托品对毒液引起的ECG变化没有影响。
