Guieu R, Kopeyan C, Sampieri F, Devaux C, Bechis G, Rochat H
Arch Toxicol. 1995;69(8):575-7. doi: 10.1007/s002040050216.
Hyperthermia and profuse perspiration are rarely absent in severe cases of scorpion envenomation. Based on these observations, the aim of this study was to determine the therapeutic effects of dantrolene, on experimental poisoning by the venom of Androctonus australis hector. Dantrolene is a directly acting muscle relaxant which lowers the body temperature in malignant hyperthermia. The results indicate that the early use of this drug raises the LD50 in experimentally poisoned mice. If these results are transposable to humans, dantrolene could be a useful therapeutic adjuvant.
在严重的蝎子蜇伤病例中，高热和大量出汗很少不存在。基于这些观察结果，本研究的目的是确定丹曲林对澳大利亚杀人蝎毒液所致实验性中毒的治疗效果。丹曲林是一种直接作用的肌肉松弛剂，可降低恶性高热时的体温。结果表明，在实验中毒的小鼠中早期使用这种药物可提高半数致死剂量（LD50）。如果这些结果可应用于人类，丹曲林可能是一种有用的治疗辅助药物。
