光动力疗法治疗与点状内层脉络膜病变（PIC）或疑似眼组织胞浆菌病样综合征（POHS样）相关的黄斑中心凹下典型脉络膜新生血管。
Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like).
作者信息
Postelmans Laurence, Pasteels Brigitte, Coquelet Pascale, Caspers Laure, Verougstraete Claire, Leys Anita, Wirix Mieke, Mauget-Faÿsse Martine, Quanranta Maddalena, Snyers Bernadette, Smets Erica
机构信息
Department of Ophthalmology, Centres Hospitaliers Universitaires Brugmann et Saint-Pierre, ULB, Bruxelles, Belgium.
出版信息
Ocul Immunol Inflamm. 2005 Sep-Oct;13(5):361-6. doi: 10.1080/09273940590951124.
PURPOSE
To evaluate the safety and efficacy of photodynamic therapy with verteporfin (PDT) for subfoveal classic choroidal neovascularization (CNV) related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like).
METHODS
Retrospective review of 16 eyes from 14 patients with subfoveal classic CNV associated with PIC or POHS-like and treated with PDT.
RESULTS
The mean visual acuity increased from 4.5/10 (range: 1/10-9/10) to 7/10 (range: 2/10-10/10) after a mean follow-up of 21 months (range: 8-32 months) and a mean number of 2 PDT (range: 1-6). Visual acuity remained stable or improved in 13 of the 16 eyes (81%) and decreased in three.
CONCLUSION
This nearly two-year follow-up study suggests that PDT could be helpful for patients with subfoveal classic CNV related to PIC or POHS-like.
目的
评估维替泊芬光动力疗法（PDT）治疗与点状内层脉络膜病变（PIC）或疑似眼组织胞浆菌病样综合征（POHS样）相关的黄斑下典型脉络膜新生血管（CNV）的安全性和有效性。
方法
回顾性分析14例患有与PIC或POHS样相关的黄斑下典型CNV并接受PDT治疗的患者的16只眼。
结果
平均随访21个月（范围：8 - 32个月），平均接受2次PDT治疗（范围：1 - 6次）后，平均视力从4.5/10（范围：1/10 - 9/10）提高到7/10（范围：2/10 - 10/10）。16只眼中有13只（81%）视力保持稳定或提高，3只眼视力下降。
结论
这项近2年的随访研究表明，PDT可能有助于治疗与PIC或POHS样相关的黄斑下典型CNV患者。
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