Gilmartin Marieke R, McEchron Matthew D
Department of Neural & Behavioral Sciences, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Behav Neurosci. 2005 Dec;119(6):1496-510. doi: 10.1037/0735-7044.119.6.1496.
Trace fear conditioning is a learning task that requires the association of an auditory conditioned stimulus (CS) and a shock unconditioned stimulus (US) that are separated by a 20-s trace interval. Single neuron activity was recorded from the prelimbic and infralimbic areas of the medial prefrontal cortex in rats during trace fear conditioning or nonassociative unpaired training. Prelimbic neurons showed learning-related increases in activity to the CS and US, whereas infralimbic neurons showed learning-related decreases in activity to these stimuli. A subset of prelimbic neurons exhibited sustained increases in activity during the trace interval. These sustained prelimbic responses may provide a bridging code that allows for overlapping representations of CS and US information within the trace fear conditioning circuit.
痕迹恐惧条件反射是一种学习任务，它要求将听觉条件刺激（CS）和电击非条件刺激（US）联系起来，二者之间间隔20秒的痕迹间隔。在痕迹恐惧条件反射或非联合性非配对训练期间，记录大鼠内侧前额叶皮质前边缘区和下边缘区的单神经元活动。前边缘区神经元对CS和US的反应表现出与学习相关的活动增加，而下边缘区神经元对这些刺激的反应则表现出与学习相关的活动减少。一部分前边缘区神经元在痕迹间隔期间表现出持续的活动增加。这些前边缘区的持续反应可能提供一种桥梁编码，使得在痕迹恐惧条件反射回路中CS和US信息能够重叠表征。
