Rorick-Kehn Linda M, Steinmetz Joseph E
Department of Psychology and Program in Neural Science, Indiana University, 1101 E. 10th Street, Bloomington, IN 47405, USA.
Behav Neurosci. 2005 Oct;119(5):1254-76. doi: 10.1037/0735-7044.119.5.1254.
Neural activity in central and basolateral amygdala nuclei (CeA and BLA, respectively) was recorded during delay eyeblink conditioning, Pavlovian fear conditioning, and signaled barpress avoidance. During paired training, the CeA exhibited robust learning-related excitatory activity during all 3 tasks. By contrast, the BLA exhibited minimal activity during eyeblink conditioning, while demonstrating pronounced increases in learning-related excitatory responsiveness during fear conditioning and barpress avoidance. In addition, the relative amount of amygdalar activation observed appeared to be related to the relative intensity of the unconditioned stimulus and somatic requirements of the task. Results suggest the CeA mediates the Pavlovian association between sensory stimuli and the BLA mediates the modulation of instrumental responding through the assignment of motivational value to the unconditioned stimulus.
在延迟眨眼条件反射、巴甫洛夫恐惧条件反射和信号压杆回避过程中，分别记录了中央杏仁核和基底外侧杏仁核（分别为CeA和BLA）的神经活动。在配对训练期间，CeA在所有3项任务中均表现出与学习相关的强烈兴奋性活动。相比之下，BLA在眨眼条件反射期间活动极少，而在恐惧条件反射和压杆回避期间，与学习相关的兴奋性反应明显增加。此外，观察到的杏仁核激活的相对量似乎与非条件刺激的相对强度和任务的躯体需求有关。结果表明，CeA介导了感觉刺激之间的巴甫洛夫关联，而BLA通过赋予非条件刺激动机价值来介导工具性反应的调节。
