Bilkey David K, Clearwater Jonathon M
Department of Psychology and Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.
Behav Neurosci. 2005 Dec;119(6):1533-45. doi: 10.1037/0735-7044.119.6.1533.
Many hippocampal neurons (place cells) appear to represent a particular location within an environment (their place field). This property would appear to be central to hippocampal involvement in navigation based on spatial memory. Although a navigationally useful representation might also include information about distal goals, having a place field and being able to represent a distal goal would appear to be mutually exclusive place cell properties. Our simulations demonstrate, however, that information about goal direction can be simply derived from the changes in place field density that occur when place fields shift location in a goal-directed manner. Previous reports that place fields respond dynamically to shifts in goal location may, therefore, represent the operation of such a system.
许多海马体神经元（位置细胞）似乎代表着环境中的一个特定位置（它们的位置野）。这一特性似乎是海马体基于空间记忆参与导航的核心。尽管一个对导航有用的表征可能还包括有关远端目标的信息，但拥有一个位置野和能够表征一个远端目标似乎是相互排斥的位置细胞特性。然而，我们的模拟表明，目标方向的信息可以简单地从位置野密度的变化中推导出来，这种变化是当位置野以目标导向的方式移动位置时发生的。因此，之前关于位置野对目标位置变化做出动态反应的报道，可能代表了这样一个系统的运作。
