Division of Psychology and Language Sciences, Department of Experimental Psychology, UCL Institute of Behavioural Neuroscience, University College London, London, UK.
Division of Biosciences, Department of Cell & Developmental Biology, University College London, UK.
Hippocampus. 2018 Sep;28(9):644-658. doi: 10.1002/hipo.22813. Epub 2017 Dec 14.
Coding the distance to a future goal is an important function of a neural system supporting navigation. While some evidence indicates the hippocampus increases activity with proximity to the goal, others have found activity to decrease with proximity. To explore goal distance coding in the hippocampus we recorded from CA1 hippocampal place cells in rats as they navigated to learned goals in an event arena with a win-stay lose-shift rule. CA1 activity was positively correlated with the distance - decreasing with proximity to the goal. The stronger the correlation between distance to the goal and CA1 activity, the more successful navigation was in a given task session. Acceleration, but not speed, was also correlated with the distance to the goal. However, the relationship between CA1 activity and navigation performance was independent of variation in acceleration and variation in speed. These results help clarify the situations in which CA1 activity encodes navigationally relevant information and the extent to which it relates to behavior.
对未来目标的距离进行编码是支持导航的神经系统的一项重要功能。虽然有一些证据表明海马体的活动随着接近目标而增加，但也有研究发现活动随着接近目标而减少。为了探索海马体中的目标距离编码，我们在大鼠在事件竞技场中导航到学习目标时，从 CA1 海马体位置细胞中进行了记录，该竞技场采用赢留输移规则。CA1 活动与距离呈正相关 - 随着接近目标而减少。距离目标的相关性越强，在给定的任务会话中导航的成功率就越高。加速度而不是速度也与目标距离相关。然而，CA1 活动与导航表现之间的关系独立于加速度和速度的变化。这些结果有助于阐明 CA1 活动编码与导航相关信息的情况，以及它与行为的关系程度。
